The validity of serum ferritin levels in predicting cardiovascular events of metabolic dysfunction-associated steatotic liver disease patients may need more consideration  

作　　者：Jie Yang Qing Liu Jie Li Chao Sun 

机构地区：[1]Department of Gastroenterology,Tianjin Medical University General Hospital Airport Hospital,Tianjin,China [2]Department of Gastroenterology and Hepatology,Tianjin Medical University General Hospital,Tianjin,China [3]Department of Infectious Diseases,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,China

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第4期755-756,共2页肝胆外科与营养（英文）

基　　金：Beijing iGandan Foundation(iGandanF-1082024-LG013).

摘　　要：We read with great interest the informative study by Armandi et al.,which shed light on the potential role of serum ferritin in predicting the long-term prognosis of patients with metabolic dysfunction-associated steatotic liver disease(1).However,there remain certain facets requiring in-depth investigation and interpretation.First of all,the study found that integrating stepwise increased ferritin thresholds(215.5 and 272µg/L)into predictive models can improve the performance of fibrosis-4(FIB-4)and Non-Alcoholic Fatty Liver Disease Fibrosis Score(NFS)in the longitudinal risk assessment of liver-related events and overall mortality.However,it has been suggested that metabolic hyperferritinaemia(MHF)appears to exhibit a male predominance(2,3).Since the study primarily comprised male participants(65%),it raises the query of whether the ferritin threshold based on the entire population can accurately predict risks within female patients.Therefore,a sex-specific analysis is warranted to ensure a more precise evaluation.

关 键 词：Metabolic dysfunction-associated steatotic liver disease(MASLD) serum ferritin cardiovascular events 

分 类 号：R575[医药卫生—消化系统]