Long-and short-term outcomes for resectable gallbladder carcinoma patients treated with curative-intent laparoscopic versus open resection:a multicenter propensity score-matched comparative study  

作　　者：Zhi-Peng Liu Xing-Xing Su Long-Fei Chen Xue-Lei Li Yi-Shi Yang Zhi-Long You Xiao-Lin Zhao Fan Huang Chao Yu Zhao-Ping Wu Wei Chen Jin-Xue Zhou Wei Guo Da-Long Yin Ping Yue Rui Ding Yi Zhu Wei Chen Yan Jiang Jie Bai Jing-Jing Wang Yan-Qi Zhang Dong Zhang Hai-Su Dai Wan Yee Lau Zhi-Yu Chen The Biliary Surgery Branch of Elite Group of Chinese Digestive Surgery(EGCDS) 

机构地区：[1]Department of Hepatobiliary Surgery,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing,China [2]Hepato-pancreato-biliary Center,Tsinghua Changgung Hospital,Tsinghua University,Beijing,China [3]Department of General Surgery,Third Affiliated Hospital of Zunyi Medical University,Zunyi,China [4]Department of General Surgery,First Affiliated Hospital of Anhui Medical University,Hefei,China [5]Department of Hepatobiliary Surgery,Affiliated Hospital of Guizhou Medical University,Guiyang,China [6]Department of Hepatopancreatobiliary Surgery,Jiujiang First People’s Hospital,Jiujiang,China [7]Department of Hepatopancreatobiliary Surgery,First Affiliated Hospital of Sun Yat-sen University,Guangzhou,China [8]Department of Hepatopancreatobiliary Surgery,Henan Provincial Tumor Hospital,Zhengzhou,China [9]Department of General Surgery,Capital Medical University Affiliated Beijing Friendship Hospital,Beijing,China [10]Department of Hepatobiliary Surgery,First Affiliated Hospital of USTC,Hefei,China [11]Department of General Surgery,Lanzhou University First Affiliated Hospital,Lanzhou,China [12]Department of Hepatopancreatobiliary Surgery,First Affiliated Hospital of Air Force Medical University,Xi’an,China [13]Department of Hepatopancreatobiliary Surgery,The Second Affiliated Hospital Zhejiang University School of Medicine,Hangzhou,China [14]Department of Health Statistics,College of Military Preventive Medicine,Third Military Medical University(Army Medical University),Chongqing,China [15]Department of Hepatobiliary Surgery,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,China [16]Faculty of Medicine,the Chinese University of Hong Kong,Hong Kong,China [17]不详

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第5期788-800,I0002,共14页肝胆外科与营养（英文）

摘　　要：Background:Gallbladder cancer(GBC)was once considered a contraindication for laparoscopic surgery,but it is becoming more common to use laparoscopic surgery for GBC treatment.The aim of this study was to analyze the long-and short-term outcomes of patients with more advanced T-staged GBC treated with curative intent as defined by the National Comprehensive Cancer Network(NCCN)after laparoscopic resection(LR)versus open resection(OR).Methods:A multicenter database was used to select consecutive GBC patients treated with curative-intent resection as defined by the NCCN between 2016 and 2020.The patients were divided into the LR group and the OR group.Propensity score matching(PSM)was used to eliminate selection bias.The endpoints were overall survival(OS),progression-free survival(PFS),and short-term outcomes.Risk factors that were independently associated with OS and PFS were identified.Results:Of 626 GBC patients treated with curative-intent resection,after PSM,51 patients were in the LR group and 153 patients were in the OR group.The LR group had more patients who were suitable to receive adjuvant chemotherapy(AC),a longer operation time,more harvested lymph nodes,and a lower overall morbidity rate.The rates of OS and PFS were not significantly different between the two groups.AC was independently associated with better OS and PFS.Conclusions:The overall morbidity of GBC patients after LR was lower,but the long-term outcomes between LR and OR were not significantly different.The GBC patients treated with LR were more likely to receive AC,and the use of AC after curative-intent resection of GBC helped achieve better long-term survival outcomes.

关 键 词：Gallbladder cancer(GBC) laparoscopic resection(LR) MORBIDITY survival adjuvant chemotherapy(AC) 

分 类 号：R735.8[医药卫生—肿瘤]