Liver transplantation for colorectal liver metastasis:the exception,not the rule  

作　　者：Diamantis I.Tsilimigras Dimitrios Schizas Anargyros Bakopoulos Timothy M.Pawlik 

机构地区：[1]Department of Surgery,Division of Surgical Oncology,The Ohio State University,Wexner Medical Center and James Comprehensive Cancer Center,Columbus,OH,USA [2]Department of Surgery,Laiko University Hospital,National and Kapodistrian University of Athens,Athens,Greece [3]Department of Surgery,Attikon University Hospital,National and Kapodistrian University of Athens,Athens,Greece

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第5期857-860,共4页肝胆外科与营养（英文）

摘　　要：Approximately half of individuals diagnosed with colorectal cancer(CRC)will develop colorectal liver metastasis(CRLM)during the course of their disease(1,2).Liver resection is the only potentially curative treatment for patients with CRLM,yet less than 20%of individuals are candidates for resection due to the extent or location of liver disease,underlying liver function and/or presence of extrahepatic metastases(1,2).In addition,the oncologic benefit of liver resection for CRLM is limited by recurrence rates than can be as high as 70%(3).Liver transplantation(LT)for CRLM was initially proposed as an alternative treatment strategy in the early 1990s but was abandoned due to the initial poor outcomes(3,4).The concept of transplantation for CRLM was later revisited in the 2000s by a group in Oslo,Norway that reported promising results in the SECA-I pilot study(5).Since the completion of the SECA-I study,the Norwegian group has also published other promising data from the SECA-II study(6).In addition,other notable outcomes have been reported in the RAPID study(7),as well as another study from specialized centers in North America(8),both of which have revitalized the concept of LT for CRLM.

关 键 词：Liver transplantation(LT) colorectal cancer(CRC) liver metastasis colorectal liver metastasis(CRLM) 

分 类 号：R735.7[医药卫生—肿瘤] R735.34[医药卫生—临床医学]