Molecular pathology for cholangiocarcinoma:a review of actionable genetic targets and their relevance to adjuvant&neoadjuvant therapy,staging,follow-up,and determination of minimal residual disease  

作　　者：Emilie A.K.Warren Shishir K.Maithel 

机构地区：[1]Division of Surgical Oncology,Winship Cancer Institute,Emory University,Atlanta,GA,USA

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第1期29-38,共10页肝胆外科与营养（英文）

摘　　要：Cholangiocarcinoma(CCA)represents a group of epithelial cell tumors classified based on their anatomic location along the biliary tree.This rare malignancy is often diagnosed at an advanced stage and deemed unresectable.Even for those patients who are surgical candidates,recurrence rates are high and survival rates low.The mainstay of therapy for advanced CCA remains cisplatin plus gemcitabine,with a median overall survival(mOS)under 12 months,although the TOPAZ-1 trial showed a survival benefit with the addition of programmed cell death ligand 1(PD-L1)blockade.In recent years,molecular profiling has revealed a wealth of potentially targetable genetic alterations,including fibroblast growth factor receptor(FGFR)fusions,isocitrate dehydrogenase 1(IDH1)mutations,human epidermal growth factor receptor 2(HER2)amplification and overexpression,and microsatellite instability(MSI).These discoveries have prompted numerous clinical trials employing drugs against these specific genetic changes.The foundation laid by early clinical studies and the landscape of ongoing trials are both summarized here.While the role of adjuvant therapy has yet to be defined in this disease,we emphasize the importance of employing targeted therapies in trials in the adjuvant and neoadjuvant spaces and discuss ways to overcome challenges due to low incidence of targetable mutations.Personalized medicine for this disease promises significant clinical benefit to patients,but further investigation is needed.

关 键 词：Cholangiocarcinoma(CCA) biliary tract cancer(BTC) targeted therapy molecular profiling 

分 类 号：R735.8[医药卫生—肿瘤]