Insights into treatment for hepatocellular carcinoma with tumor thrombus in the inferior vena cava or right atrium  

作　　者：Jia Yang Yongjie Shui Lihong Liu Genhua Yu Qichun Wei 

机构地区：[1]Department of Radiation Oncology,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China [2]The Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Zhejiang University School of Medicine,Hangzhou,China

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第1期168-171,共4页肝胆外科与营养（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(No.82203078,J.Y.,No.82073332,Q.W.);Natural Science Foundation of Zhejiang Province(No.LQ22H160030,J.Y.).

摘　　要：Hepatocellular carcinoma(HCC),one of the most common liver cancers,often has a poor prognosis when it involves macrovascular invasion.Oncological emergencies including pulmonary embolism,heart failure,and even sudden death could happen when it develops a tumor thrombus(TT)in the inferior vena cava(IVC)or right atrium(RA),indicating an exceptionally grim prognosis(1).Although systemic therapy is the only standard treatment recommended by guidelines(2),other treatment modalities are explored including surgery,radiotherapy,etc.in some centers.Surgery,as the only potential curative treatment,has been explored in several selected cases.A case of long-term survival of 15 years and cancer-free survival of 9 years was reported by surgical resection with a heart-first approach under cardiopulmonary bypass(CPB)(3),suggesting that aggressive surgery together with multidisciplinary treatments might achieve long survival.However,due to the aggressiveness and challenge of surgical resection-massive resection area,potential significant blood loss,and bypass needed,surgical resection is applied in very limited centers.Nevertheless,safety,efficacy,and long-term survival benefits for these patients are poorly investigated.

关 键 词：Hepatocellular carcinoma(HCC) inferior vena cava(IVC) right atrium(RA) tumor thrombus(TT) 

分 类 号：R735.7[医药卫生—肿瘤]