Non-alcoholic fatty pancreas disease: an updated review  

作　　者：Chaoyu Pang Peng Dong Jian Yang Zhiyao Fan Zhiqiang Cheng Hanxiang Zhan 

机构地区：[1]Division of Pancreatic Surgery,Department of General Surgery,Qilu Hospital,Shandong University,Jinan 250012,China [2]Division of Colorectal Surgery,Department of General Surgery,Qilu Hospital,Shandong University,Jinan 250012,China

出　　处：《Journal of Pancreatology》2024年第3期212-221,共10页胰腺病学杂志（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(81972274,81702365);Taishan Scholars Program for Young Expert of Shandong Province(tsqn202103172);Shandong Provincial Natural Science Foundation(ZR2021LSW004,ZR2017MH090);Clinical Research Foundation of Shandong University(2020SDUCRCC016).

摘　　要：Ectopic accumulation of fat can cause a variety of metabolic diseases,and the emerging non-alcoholic fatty pancreas disease(NAFPD)is increasingly being recognized by clinicians as a cause for concern.NAFPD is a disease caused by abnormal accumulation of adipose tissue in the pancreas,which is related to obesity.The main feature of NAFPD is death of acinar cells,which are then replaced by adipose cells.However,the underlying molecular mechanisms have not been fully explored.Obesity,aging,and metabolic syndrome are independent risk factors for the occurrence and development of NAFPD.Studies have shown that NAFPD leads to insulin resistance and pancreatic dysfunction,increases the risk of diabetes mellitus,worsens the severity of pancreatitis,and is significantly correlated with pancreatic cancer and postoperative pancreatic fistula.There is no standard treatment for NAFPD;exercise,a balanced diet,and lifestyle can help reduce pancreatic fat;however,other treatment modalities such as drugs and bariatric surgery are still being explored.The specific pathological mechanism of NAFPD remains unclear,and its potential association with various clinical diseases requires further study.This review summarizes the etiology,diagnosis,clinical consequences,and potential therapeutic strategies of NAFPD.

关 键 词：Metabolic syndrome Non-alcoholic FATTY pancreas disease Obesity PANCREATIC cancer PANCREATIC steatosis 

分 类 号：R576[医药卫生—消化系统]