Yes关联蛋白1在食管鳞状细胞癌中的临床意义  

Clinical significance of Yes-associated protein 1 in esophageal squamous cell carcinoma

作　　者：刘坤 管瑛瑛 蒋冬先 许惠娟 侯英勇 侯君 LIU Kun;GUAN Yingying;JIANG Dongxian;XU Huijuan;HOU Yingyong;HOU Jun(Department of Pathology,Zhongshan Hospital(Xiamen Branch),Fudan University,Xiamen 361015,Fujian,China;Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province,Xiamen 361015,Fujian,China;Department of Pathology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院厦门医院病理科,厦门361015 [2]福建省腹部肿瘤精准诊疗临床医学研究中心,厦门361015 [3]复旦大学附属中山医院病理科,上海200032

出　　处：《中国临床医学》2024年第5期772-777,共6页Chinese Journal of Clinical Medicine

基　　金：福建省卫生健康科技计划项目(2023QNB011);厦门市医疗卫生指导性项目(3502Z20224ZD1089,3502Z20244ZD1125);复旦大学附属中山医院厦门医院院级孵化课题(2018ZSXMYJ01)。

摘　　要：目的探讨Yes关联蛋白1(Yes-associated protein 1,YAP1)在食管鳞状细胞癌组织中的表达情况及临床意义。方法采用免疫组化技术检测439例食管鳞状细胞癌患者癌组织中YAP1的表达,分析YAP1阳性组与阴性组患者的临床病理参数差异。采用Kaplan-Meier生存曲线分析YAP1对患者生存的影响。结果食管鳞状细胞癌中,YAP1的阳性率为30.52%(134/439)。YAP1阳性组患者肿瘤浸润更深(P<0.001)。Kaplan-Meier生存曲线分析显示,在生存期长于30个月的患者中,YAP1阳性者无瘤生存期(disease-free survival,DFS)和总生存期(overall survival,OS)更长(P<0.05)。Cox多因素回归分析显示,浸润深度是影响患者DFS(HR=1.371,95%CI 0.993~1.894,P=0.035)和OS(HR=1.489,95%CI 1.066~2.080,P=0.020)的独立因素。结论YAP1在部分食管鳞状细胞癌中表达;对于生存期大于30个月的患者,YAP1表达阳性提示预后更好。Objective To explore the expression and clinical significance of Yes-associated protein 1(YAP1)in esophageal squamous cell carcinoma.Methods Immunohistochemical method was used to detect YAP1 expression in 439 cases of esophageal squamous cell carcinoma.The differences of YAP1 expression and clinical parameters were analyzed between YAP1 positive group and YAP1 negative group.Kaplan-Meier curve was used to analyze the influence of YAP1 expression on survival of patients.Results The positive rate of YAP1 in esophageal squamous cell carcinoma was 30.52%.The tumor invasion was deeper in YAP1 positive group(P<0.001).Kaplan-Meier survival analysis showed that YAP1 positive patients had longer disease-free survival(DFS)and overall survival(OS)among patients surviving longer than 30 months(P<0.05).The multivariate Cox regression analysis showed that the invasion depth of tumor was an independent factor affecting DFS(HR=1.371,95%CI 0.993-1.894,P=0.035)and OS(HR=1.489,95%CI 1.066-2.080,P=0.020).Conclusions YAP1 has a certain percentage of positive rate in esophageal squamous cell carcinoma;for patients with survival longer than 30 months,YAP1 positive indicates a better prognosis.

关 键 词：食管鳞状细胞癌 Yes关联蛋白1 预后 

分 类 号：R735.1[医药卫生—肿瘤]