Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders:from molecular mechanisms to clinical implications  

作　　者：Jinyu Zhao Ping Yue Ningning Mi Matu Li Wenkang Fu Xianzhuo Zhang Long Gao Mingzhen Bai Liang Tian Ningzu Jiang Yawen Lu Haidong Ma Chunlu Dong Yong Zhang Hengwei Zhang Jinduo Zhang Yanxian Ren Azumi Suzuki Peng F.Wong Kiyohito Tanaka Rungsun Rerknimitr Henrik H.Junger Tan T.Cheung Emmanuel Melloul Nicolas Demartines Joseph W.Leung Jia Yao Jinqiu Yuan Yanyan Lin Hans J.Schlitt Wenbo Meng 

机构地区：[1]Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou,Gansu,China [2]The First School of Clinical Medicine,Lanzhou University,Lanzhou,Gansu 730000,China [3]Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province,Lanzhou,Gansu 730000,China [4]Clinical Research Center,Big Data Center,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen,Guangdong 518000,China [5]Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou,Gansu 730000,China [6]Department of Surgery,University Medical Center Regensburg,93053 Regensburg,Germany

出　　处：《Medical Review》2024年第4期326-365,共40页医学评论（英文）

基　　金：supported by the National Key Research and Development Program of China (2022YFC2407405);the Joint Research Fund Major Project of Gansu Province (23JRRA1488);the Medical Innovation and Development Project of Lanzhou University (lzuyxcx-2022-157).

摘　　要：Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and mortality.Biliary fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders,which may promote the development and progression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract injuries.Elucidating the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary diseases.In this review,we emphasized the importance of biliary fibrosis in cholangiopathies and summarized the clinical manifestations,epidemiology,and aberrant cellular composition involving the biliary ductules,cholangiocytes,immune system,fibroblasts,and the microbiome.We also focused on pivotal signaling pathways and offered insights into ongoing clinical trials and proposing a strategic approach for managing biliary fibrosis-related cholangiopathies.This review will offer a comprehensive perspective on biliary fibrosis and provide an important reference for future mechanism research and innovative therapy to prevent or reverse fibrosis.

关 键 词：biliary fibrosis CHOLANGIOPATHY ETIOLOGY mechanism therapeutic strategy 

分 类 号：R575[医药卫生—消化系统]