高危型人乳头状瘤病毒感染与宫颈鳞状上皮癌组织相关受体水平的相关性  

Correlation Between High-Risk Human Papillomavirus Infection and Related Receptor Levels in the Tissues of Cervical Squamous Epithelial Carcinoma

作　　者：杨向君 李小华[1] 李莹莹 门楠[1] Yang Xiangjun;Li Xiaohua;Li Yingying;Men Nan(Department of Pathology,Tangshan Maternal and Child Health Hospital,Tangshan 063000,China)

机构地区：[1]唐山市妇幼保健院病理科,唐山063000

出　　处：《成都医学院学报》2024年第5期836-840,共5页Journal of Chengdu Medical College

基　　金：河北省卫生健康委员会医学科学研究课题计划项目(No:20221759)。

摘　　要：目的探究高危型人乳头状瘤病毒(HR-HPV)感染与宫颈鳞状上皮癌(CSES)组织中抗原分化因子受体2(C-ERBB-2)、人类表皮生长因子受体2(HER-2)水平的相关性。方法选取2021年9月至2023年9月唐山市妇幼保健院收治的100例CSES患者作为CSES组,另纳入同期于本院接受治疗的宫颈上皮内瘤变(CIN)和宫颈炎患者各90例分别作为CIN组和宫颈炎组,采用免疫组织化学法测定HER-2、C-ERBB-2表达水平,分析HR-HPV感染与CSES组织中C-ERBB-2、HER-2水平的相关性。结果与宫颈炎组比较,CIN组和CSES组的HR-HPV阳性感染率以及C-ERBB-2、HER-2阳性表达率均上升(P<0.05);与CIN组比较,CSES组HR-HPV阳性感染率明显升高(P<0.05),C-ERBB-2、HER-2阳性表达率比较,差异无统计学意义(P>0.05)。年龄≥55岁、TNM分期Ⅲ~Ⅳ期、分化程度为低分化以及有淋巴结转移的C-ERBB-2、HER-2阳性表达和HR-HPV感染阳性的患者比例高于年龄<55岁、TNM分期Ⅰ~Ⅱ期、分化程度为中/高分化、无淋巴结转移的CSES患者(P<0.05)。HR-HPV感染阳性的CSES患者病变组织中C-ERBB-2、HER-2阳性表达率高于HR-HPV感染阴性的CSES患者(P<0.05)。结论CSES病变组织中C-ERBB-2、HER-2高表达,并与HR-HPV感染有关,C-ERBB-2、HER-2可作为CSES诊断和治疗的靶点。Objective To explore the correlation between high-risk human papillomavirus(HR-HPV)infection and the levels of antigen differentiation factor receptor 2(C-ERBB-2)and human epidermal growth factor receptor 2(HER-2)in the tissues of cervical squamous epithelial carcinoma(CSES)patients.Methods A total of 100 CSES patients admitted to Tangshan Maternal and Child Health Hospital from September 2021 to September 2023 were selected as the CSES group,90 patients with cervical intraepithelial neoplasia(CIN)and 90 patients with cervicitis who received treatment in the hospital during the same period were included as the CIN group,and the cervicitis group,respectively.The expression levels of C-ERBB-2 and HER-2 were determined by immunohistochemistry.The relationship between HR-HPV infection and the levels of C-ERBB-2 and HER-2 in CSES tissues was analyzed.Results The positive rate of HR-HPV infection and the positive expression rates of C-ERBB-2 and HER-2 in the CIN and CSES groups were higher than those in the cervicitis group(P<0.05).The positive rate of HR-HPV infection in the CSES group was higher than that in the CIN group(P<0.05),while there was no significant difference in the positive expression rates of C-ERBB-2 and HER-2 between the two groups(P>0.05).The proportions of C-ERBB-2,HER-2 positive,and HR-HPV positive in CSES patients with age≥55 years old,tumor node metastasis(TNM)stage III-IV,low differentiation,and lymph node metastasis were obviously higher than those in CSES patients with age<55 years old,TNM stage I-II,medium/high differentiation,and non lymph node metastasis(P<0.05).The positive expression rates of C-ERBB-2 and HER-2 in the tissues of CSES patients with positive HR-HPV infection were higher than those of CSES patients with negative HR-HPV infection(P<0.05).Conclusion C-ERBB-2 and HER-2 are highly expressed in the tissues of CSES patients,which is associated with HR-HPV infection.C-ERBB-2 and HER-2 may serve as targets for the diagnosis and treatment of CSES.

关 键 词：宫颈鳞状上皮癌 抗原分化因子受体2 人类表皮生长因子受体2 高危型人乳头状瘤病毒 

分 类 号：R737.33[医药卫生—肿瘤]