A chromosome-scale genome assembly of Rauvolfia tetraphylla facilitates identification of the complete ajmaline biosynthetic pathway  

作　　者：Enzo Lezin Ines Carqueijeiro Clement Cuello Mickael Durand Hans JJansen Valentin Verges Caroline Birer Williams Audrey Oudin Thomas Duge de Bernonville Julien Petrignet Noemie Celton Benoit St-Pierre Nicolas Papon Chao Sun Ron P.Dirks Sarah Ellen O’Connor Michael Krogh Jensen Sebastien Besseau Vincent Courdavault 

机构地区：[1]Biomole´cules et Biotechnologies Vegetales,EA2106,Universite´de Tours,37200 Tours,France [2]Future Genomics Technologies,2333 BE Leiden,the Netherlands [3]Laboratoire Synthe se et Isolement de Molecules BioActives(SIMBA,EA 7502),Universitede Tours,37200 Tours,France [4]Laboratoire de Cytoge´netique Constitutionnelle,CHRU de Tours-Hopital Bretonneau,37044 Tours,France [5]University Angers,University Brest,IRF,SFR ICAT,49000 Angers,France [6]Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 2800,China [7]Department of Natural Product Biosynthesis,Max Planck Institute for Chemical Ecology,07745 Jena,Germany [8]Novo Nordisk Foundation Center for Biosustainability,Technical University of Denmark,100193 Kgs Lyngby,Denmark [9]Present address:Limagrain,Center de Recherche,Route d’Ennezat,Chappes,France [10]These authors contributed equally to this article

出　　处：《Plant Communications》2024年第4期129-132,共4页植物通讯（英文）

基　　金：supported by the EU Horizon 2020 research and innovation program (MIAMi project-grant agreement N°814645);the ARD CVL Biopharmaceutical program of the Region Centre-Val de Loire (ETOPOCentre project);the ANR (project MIACYC–ANR-20-CE43-0010).

摘　　要：Dear Editor,Rauvolfia tetraphylla(aka the Devil pepper)(Supplemental Figure 1)is a well-known medicinal plant that produces monoterpenoid indole alkaloids(MIAs).This MIA biosynthesis occurs in several organs,including leaves,stems,fruit,and roots,which accumulate the famous antiarrhythmic ajmaline(Kumar et al.2016a,2016b;Kumara et al.,2019).MIAs are natural products notably involved in plant adaptation to the environment and defense against aggressors.This mainly results from their high biological activities,which also explain their pharmacological properties.

关 键 词：properties FIGURE ROOTS 

分 类 号：Q94[生物学—植物学]