Expression of SALL4 in the synovial tissue of refractory rheumatoid arthritis patients  

作　　者：Ru Fan Zeqiong Liang Yujie Bu Fen Zhang Xing Cen Yuqing Liu Fenping Lian Fengwu Chen Shengxiao Zhang Junwei Chen 

机构地区：[1]Department of Rheumatology,The Second Hospital of Shanxi Medical University,Taiyuan,China [2]State Key Laboratory of Multiphase Flow in Power Engineering,Xi'an Jiaotong University,Xi'an,Shaanxi,China [3]Key Laboratory of Cellular Physiology at Shanxi Medical University,Ministry of Education,Taiyuan,China [4]Shanxi Provincial Key Laboratory of Rheumatism Immune Microecology,The Second Hospital of Shanxi Medical University,Taiyuan,China

出　　处：《Rheumatology & Autoimmunity》2024年第1期59-61,共3页风湿病与自身免疫（英文）

基　　金：Shanxi Provincial Department of Science and Technology(Grant/Award Number:201803D421072).

摘　　要：To the Editor,Rheumatoid arthritis(RA)synovitis is characterized by synovial inflammation,characterized by synovial proliferation,neovascularization,and leukocyte infiltration into the joint space,1 leading to irreversible cartilage and bone damage.2 This synovial inflammation stimulates the formation of pannus,which is an invasive tumor-like mass,ultimately contributing to the pathogenesis of RA.RA shares several similarities with cancer,including joint pain,swelling,and stiffness,which are accompanied by hypoxia in the synovial tissue and tumor environment.3 Spalt-like transcription factor 4(SALL4)plays an essential role in the occurrence and development of tumors.4 However,SALL4 expression in synovial tissue of RA is yet to be investigated.This study aimed to investigate SALL4 expression in synovial tissue derived from patients with RA,using immunohistochemical techniques.

关 键 词：SALL4 PATIENTS INFLAMMATION 

分 类 号：R593.22[医药卫生—内科学]