Mitochondrial aberrations in systemic lupus erythematosus pathogenesis:Insights and therapeutic implications  

作　　者：Haoguang Li Lu Zhou Wei Zhou Xiuling Zhang Jingjing Shang Xueqin Feng Le Yu Jie Fan Jie Ren Rongwei Zhang Xinwang Duan 

机构地区：[1]Department of Rheumatology and Immunology,The Second Affiliated Hospital of Nanchang University,Nanchang,China

出　　处：《Rheumatology & Autoimmunity》2024年第2期69-80,共12页风湿病与自身免疫（英文）

基　　金：Key Research and Development Program of Jiangxi Municipal Science and Technology Department,Grant/Award Number:20192BBGL70024;Science and Technology Program of Department of Health of Jiangxi Province,Grant/Award Number:20204254;National Key Research and Development Program of China,Grant/Award Number:2021YFC2501304。

摘　　要：Systemic lupus erythematosus(SLE),a chronic autoimmune disease,is marked by impaired immune tolerance and heightened activity in both innate and adaptive immune systems.Hallmarks of SLE include elevated type I interferons and autoantibody production,though the exact causes of SLE remain elusive despite advances in research techniques.Crucial to SLE research is understanding its pathogenesis and developing effective diagnostic and therapeutic methods.Recent studies have highlighted a significant link between mitochondrial abnormalities and SLE's development and progression.Mitochondrial dysfunction plays a key role in SLE pathogenesis through various mechanisms such as mitochondrial DNA mutations,oxidative stress,immune metabolic reprogramming,and cellular death.These factors collectively contribute to the loss of self-tolerance,increased autoantibody production,and impaired clearance of immune complexes,leading to their deposition.This triggers sustained inflammatory responses and damages multiple organs.This review focuses on the diagnostic and therapeutic approaches related to mitochondrial abnormalities in SLE.Targeting mitochondrial pathways presents a promising strategy for treating SLE,potentially improving prognosis and quality of life for those affected.Future research should further investigate the role of mitochondria in the onset and progression of SLE,providing new avenues for understanding and managing this complex disease.

关 键 词：mitochondrial dysfunctions MITOPHAGY oxidative stress systemic lupus erythematosus therapeutic potential 

分 类 号：R593.241[医药卫生—内科学]