Effects of the Pituitary-targeted Gland Axes on Hepatic Lipid Homeostasis in Endocrine-associated Fatty Liver Disease-A Concept Worth Revisiting  

作　　者：Yifang Li Meina Zheng Steven Limbara Shanshan Zhang Yutao Yu Le Yu Jian Jiao 

机构地区：[1]Department of Gastroenterology&Hepatology,China-Japan Union Hospital,Jilin University,Changchun,Jilin,China

出　　处：《Journal of Clinical and Translational Hepatology》2024年第4期416-427,共12页临床与转化肝病杂志（英文版）

基　　金：supported in part by a grant from the Jilin Province Health Talent Special Project(2022scz01,2020scz59);the Jilin Provincial Department of Science and Technology Project(20230508073RC).

摘　　要：Hepatic lipid homeostasis is not only essential for maintain-ing normal cellular and systemic metabolic function but is also closely related to the steatosis of the liver.The contro-versy over the nomenclature of non-alcoholic fatty liver dis-ease(NAFLD)in the past three years has once again sparked in-depth discussions on the pathogenesis of this disease and its impact on systemic metabolism.Pituitary-targeted gland axes(PTGA),an important hormone-regulating system,are indispensable in lipid homeostasis.This review focuses on the roles of thyroid hormones,adrenal hormones,sex hor-mones,and their receptors in hepatic lipid homeostasis,and summarizes recent research on pituitary target gland axes-related drugs regulating hepatic lipid metabolism.It also calls on researchers and clinicians to recognize the concept of endocrine-associated fatty liver disease(EAFLD)and to re-examine human lipid metabolism from the macroscopic perspective of homeostatic balance.

关 键 词：Lipid homeostasis Metabolism Pituitary-target gland axes(PTGA) Endocrine-associated fatty liver disease(EAFLD) 

分 类 号：R575[医药卫生—消化系统]