Subnormal Serum Liver Enzyme Levels:A Review of Pathophysiology and Clinical Significance  

作　　者：Elham M.Youssef George Y.Wu 

机构地区：[1]Biochemistry Department,National Research Center,Cairo,Egypt [2]Department of Medicine,Division of Gastroenterology-Hepatology,University of Connecticut Health Center,Farmington,CT,USA

出　　处：《Journal of Clinical and Translational Hepatology》2024年第4期428-435,共8页临床与转化肝病杂志（英文版）

摘　　要：Subnormal levels of liver enzymes,below the lower limit of normal on local laboratory reports,can be useful diagnostically.For instance,subnormal levels of aminotransferases can be observed in vitamin B6 deficiency and chronic kidney disease.Subnormal alkaline phosphatase levels may indicate the presence of hypophosphatasia,Wilson's disease,deficiencies of divalent ions,or malnutrition.Subnormal levels of gamma glutamyl transferase may be seen in cases of acute intrahepatic cholestasis,the use of certain medications,and in bone disease.Finally,subnormal levels of 5'-nucleotidase have been reported in lead poisoning and nonspherocytic hemolytic anemia.The aim of this review is to bring attention to the fact that subnormal levels of these enzymes should not be ignored as they may indicate pathological conditions and provide a means of early diagnosis.

关 键 词：TRANSAMINASES Vitamin B6 Celiac disease Renal insufficiency Hepatolenticular Degeneration Crohn disease MALNUTRITION CLOFIBRATE Bone diseases Lead poisoning Anemia HEMOLYTIC 

分 类 号：R575[医药卫生—消化系统]