Focal Nodular Hyperplasia: A Comprehensive Review with a Particular Focus on Pathogenesis and Complications  

作　　者：Jaimy Villavicencio Kim George Y.Wu 

机构地区：[1]Division of Gastroenterology-Hepatology,University of Connecticut Health Center,Farmington,CT,USA

出　　处：《Journal of Clinical and Translational Hepatology》2024年第2期182-190,共9页临床与转化肝病杂志（英文版）

摘　　要：Focal nodular hyperplasia is a benign tumor of the liver that is often found incidentally with imaging.The purpose of this review is to discuss the pathophysiology,rare complications that can occur due to these lesions,and management options.A literature review was performed on clinical trials and case reports involving focal nodular hyperplasia complications and management of these,as well as the proposed pathogenesis underlying these tumors.Although exposure to oral contraceptive pills and endogenous hormones have been thought to play a role in the development of these lesions,this has not been proven.Most recently,they are thought to arise as a consequence of a vascular anomaly causing alterations in the expression of angiopoietin genes.Complications are rare,but previous cases have reported associated pain,rupture and compression of nearby structures(hepatic vein,stomach,biliary system).Resection of focal nodular hyperplasia is not usually recommended.However,if there is associated pain with no other identifiable cause or presence of a large or growing lesion with risk of causing a complication,then surgical resection,radiofrequency ablation or arterial embolization should be considered.

关 键 词：Focal nodular hyperplasia Oral contraceptives Liver lesion 

分 类 号：R735.7[医药卫生—肿瘤]