Liver Lesions at Risk of Transformation into Hepatocellular Carcinoma in Cirrhotic Patients:Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement  

作　　者：NicolòBrandi Matteo Renzulli 

机构地区：[1]Department of Radiology,IRCCS Azienda Ospedaliero-Universitaria di Bologna,Bologna,Italy

出　　处：《Journal of Clinical and Translational Hepatology》2024年第1期100-112,共13页临床与转化肝病杂志（英文版）

摘　　要：Recent technical advances in liver imaging and surveillance for patients at high risk for developing hepatocellular carcinoma(HCC)have led to an increase in the detection of borderline hepatic nodules in the gray area of multistep carcinogenesis,particularly in those that are hypointense at the hepatobiliary phase(HBP)and do not show arterial phase hyperenhancement.Given their potential to transform and advance into hypervascular HCC,these nodules have progressively attracted the interest of the scientific community.To date,however,no shared guidelines have been established for the decision management of these borderline hepatic nodules.It is therefore extremely important to identify features that indicate the malignant potential of these nodules and the likelihood of vascularization.In fact,a more complete knowledge of their history and evolution would allow outlining shared guidelines for their clinical-surgical management,to implement early treatment programs and decide between a preventive curative treatment or a watchful follow-up.This review aims to summarize the current knowledge on hepatic borderline nodules,particularly focusing on those imaging features which are hypothetically correlated with their malignant evolution,and to discuss current guidelines and ongoing management in clinical practice.

关 键 词：Nonhypervascular hypointense nodule Hepatocellular carcinoma Magnetic resonance imaging Gd-EOB LIVER 

分 类 号：R575.2[医药卫生—消化系统] R735.7[医药卫生—内科学]