Emerging bedaquiline resistance:A threat to the global fight against drug-resistant tuberculosis  

作　　者：Prakasini Satapathy Ramaiah Itumall Ahmad Neyazi Abdul Mobin Nabizai Taraki Mahalaqua Nazli Khatib Shilpa Gaidhane Quazi Syed Zahiruddin Sarvesh Rustagi Mehrab Neyazi 

机构地区：[1]Center for Global Health Research,Saveetha Medical College and Hospital,Saveetha Institute of Medical and Technical Sciences,Saveetha University,Chennai,India [2]Medical Laboratories Techniques Department,AL-Mustaqbal University,51001 Hillah,Babil,Iraq [3]School of Management,The Apollo University,Chittoor,Andhra Pradesh 517127,India [4]Afghanistan Center for Epidemiological Studies,Afghanistan [5]Division of Evidence Synthesis,Global Consortium of Public Health and Research,Datta Meghe Institute of Higher Education,Wardha,India [6]One Health Centre(COHERD),Jawaharlal Nehru Medical College,Datta Meghe Institute of Higher Education,Wardha,India [7]South Asia Infant Feeding Research Network(SAIFRN),Division of Evidence Synthesis,Global Consortium of Public Health and Research,Datta Meghe Institute of Higher Education,Wardha,India [8]School of Applied and Life Sciences,Uttaranchal University,Dehradun,Uttarakhand,India

出　　处：《Journal of Biosafety and Biosecurity》2024年第1期13-15,共3页生物安全和生物安保杂志（英文）

摘　　要：Bedaquiline resistance is increasingly observed in the treatment of rifampicin-resistant tuberculosis(TB),yet standardized regimens for managing bedaquiline-resistant TB are lacking.Studies indicate a high proportion of bedaquiline-resistant cases have previously been treated for TB,and often involve strains resistant to quinolones.Regular monitoring of the culture status in patients receiving bedaquiline resistance treatment is advised.Methods such as experimental evolution,protein modeling,genome sequencing,and phenotypic analysis have been instrumental in identifying the mechanisms of bedaquiline resistance.Specifically,variants in the Rv0678 transcriptional repressor of the MmpS5-MmpL5 efflux system are linked to this type of resistance.Bayesian probability estimates show promise in determining the genotypic–phenotypic association for bedaquiline resistance,suggesting potential utility in clinical practice.Future research should explore the practical application of Bayesian probabilities in managing bedaquiline resistance.Sequencing-based technologies are anticipated to play a vital role in the early detection and management of drug-resistant TB strains.

关 键 词：Bedaquiline Resistance DRUG-RESISTANT TUBERCULOSIS Quinolone Resistance 

分 类 号：R52[医药卫生—内科学]