DRUG-RESISTANT

作品数：118被引量：270H指数：9
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相关领域：医药卫生更多>>
相关作者：刘洋张亚培司英健高蕾陈琪更多>>
相关机构：温州医科大学天津医科大学宁波大学第四军医大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划高等学校学科创新引智计划广东省自然科学基金更多>>
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Efficacy of Pudilan Xiaoyan Oral Liquid in the treatment of pneumonia induced by drug-resistant Pseudomonas aeruginosa
《Infectious Diseases Research》2024年第3期22-29,共8页Jing Ma Yan-Yan Bao Xiao-Rui Wang Kuok Kuantai Leong-Man Chon Xiao-Lan Cui Ju-Ying Zhong Yu-Jing Shi 
supported by Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021B015);the Fundamental Research Funds for the Central Public Welfare Research Institutes(JJPY2022017).
Background:Pudilan Xiaoyan Oral Liquid(PDL)is a Chinese patent medicine with notable pharmacological properties,including anti-inflammatory and antibacterial effects.Drug-resistant Pseudomonas aeruginosa infection is ...
关键词：PUDILAN Pseudomonas aeruginosa drug resistance mice model 
Clinical efficacy and computed tomography diagnostic value of bedaquiline-containing regimens in the treatment of drug-resistant pulmonary tuberculosis
《iLABMED》2024年第3期149-156,共8页Saiduo Liu Xinchun Ye Fang Cheng Kaijia Wu Jiandan Yu Hongye Ning Jichan Shi Hongzhou Lu Wei Chen 
2021 Science and Technology Bureau Project of Wenzhou City,Zhejiang Province,Grant/Award Numbers:Y20211047,Y20210844。
Objective:This study investigated the clinical efficacy of bedaquilinecontaining regimens in the treatment of drug-resistant pulmonary tuberculosis and the diagnostic value of computed tomography(CT).Methods:We retros...
关键词：bedaquiline tablets computed tomography drug‐resistant pulmonary tuberculosis EFFICACY pulmonary tuberculosis 
Low Concentration of Wenyang Tonglin Decoction Promotes Conjugation and Transfer of Drug-Resistant Plasmids among Heterologous Strains
《Chinese Journal of Integrative Medicine》2024年第8期721-728,共8页WANG Bi-yan BU Hong-shi XIA Li-bo JIANG Xiang-yu TONG Yan-qing 
Supported by the National Natural Science Foundation of China(No.81873070)。
Objective To investigate the effect of low concentration of Wenyang Tonglin Decoction(WTD)on the binding conditions of R45 plasmid conjugative transfer under liquid phase conjugation and its mechanism.Methods Escheric...
关键词：urinary tract infection Chinese medicine drug-resistant plasmid heterozygous strains CONJUGATION transfer 
The delivery of N-myc downstream-regulated gene 2(NDRG2)self-amplifying mRNA via modified lipid nanoparticles as a potential treatment for drug-resistant and metastatic cancers
《Medical Review》2024年第3期235-238,共4页Sandra E.Reznik Amit K.Tiwari Vivek Chavda Charles R.Ashby Jr. 
The protein,N-myc downstream-regulated gene 2(NDRG2),a tumor suppressor,is significantly decreased or absent in many types of cancer.There is a significant negative correlation between the levels of NDRG2 and the deve...
关键词：N-myc downstream-regulated gene 2(NDRG2) cancer self-amplifying mRNA nanoparticle 
Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori被引量：1
《World Journal of Gastroenterology》2024年第24期3086-3105,共20页Miao-Miao Lin Shan-Shan Yang Qiu-Yue Huang Guang-Hui Cui Xiao-Fen Jia Yao Yang Zong-Ming Shi Hui Ye Xue-Zhi Zhang 
Supported by the National Natural Science Foundation of China,No.81973615 and No.82304930;Natural Science Foundation of Beijing,No.7332323;Capital’s Funds for Health Improvement and Research,No.CF2022-2-40711.
BACKGROUND Helicobacter pylori(HP),the most common pathogenic microorganism in stomach,can induce inflammatory reactions in the gastric mucosa,causing chronic gastritis and even gastric cancer.HP infection affects ove...
关键词：Qingre Huashi decoction Helicobacter pylori Drug resistance BIOFILM Metabolomics 
Inhibition of quorum sensing in drug-resistant Staphylococcus epidermidis by flavaspidic acid BB
《Traditional Medicine Research》2024年第5期33-40,共8页Xiao-Fan Xiao Xiao-Feng Chen Shi-Qian Zheng Rong-Rong Deng Zhi-Bin Shen 
Background:To investigate the effect of flavaspidic acid BB(BB)on biofilms and quorum sensing-related genes of drug-resistant Staphylococcus epidermidis(SE)and to provide a theoretical basis for the development of BB ...
关键词：Dryopteris fragrans(L.)Schott flavaspidic acid BB Staphylococcus epidermidis BIOFILM quorum sensing 
Harnessing antimicrobial peptide-coupled photosensitizer to combat drug-resistant biofilm infections through enhanced photodynamic therapy被引量：1
《Acta Pharmaceutica Sinica B》2024年第4期1759-1771,共13页Duoyang Fan Xiaohui Liu Yueming Ren Ziheng Luo Yanbing Li Jie Dong Seraphine VWegner Fei Chen Wenbin Zeng 
The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China(grant Nos.82272067,81971678,22107123,and M-0696);Natural Science Foundation of Hunan Province(grant Nos.2022JJ80052,2022JJ40656,20231120077,China);Scientific Research Fund of Hunan Provincial Education Department(22B0009,China);the Central South University Innovation-Driven Research Program(2023CXQD004,China).
Bacterial biofilm-associated infection was one of the most serious threats to human health. However, effective drugs for drug-resistance bacteria or biofilms remain rarely reported. Here, we propose an innovative stra...
关键词：Photodynamic therapy Antimicrobial peptides Multidrug-resistant bacteria Aggregation-induced emission Anti-biofilm 
Electroluminodynamic therapy for the treatment of drug-resistant pathogen infection
《Biomedical Engineering Communications》2024年第1期21-22,共2页Si-Wen Du Jin-Gai Jiang Bo-Han Li Hui-Juan Cheng Yan-Ni Song Fang-Fang Wang Dong-Liang Yang 
supported by the Natural Science Foundation of Jiangsu Province(BK20200710).
The administration of antibiotics has been the primary strategy for combating bacterial infections[1,2].However,the widespread and excessive use of antibiotics has resulted in the alarming rise of bacterial resistance...
关键词：TREATMENT INFECTION DYNAMIC 
Emerging bedaquiline resistance:A threat to the global fight against drug-resistant tuberculosis
《Journal of Biosafety and Biosecurity》2024年第1期13-15,共3页Prakasini Satapathy Ramaiah Itumall Ahmad Neyazi Abdul Mobin Nabizai Taraki Mahalaqua Nazli Khatib Shilpa Gaidhane Quazi Syed Zahiruddin Sarvesh Rustagi Mehrab Neyazi 
Bedaquiline resistance is increasingly observed in the treatment of rifampicin-resistant tuberculosis(TB),yet standardized regimens for managing bedaquiline-resistant TB are lacking.Studies indicate a high proportion ...
关键词：Bedaquiline Resistance DRUG-RESISTANT TUBERCULOSIS Quinolone Resistance 
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants
《Acta Pharmaceutica Sinica B》2024年第3期1257-1282,共26页Zhao Wang Heng Zhang Zhen Gao Zihao Sang Erik De Clercq Christophe Pannecouque Dongwei Kang Peng Zhan Xinyong Liu 
financial support from the National Natural Science Foundation of China(NSFC nos.81973181 and 81903453);Science Foundation for Outstanding Young Scholars of Shandong Province(ZR2020JQ31,China);Science Foundation for Excellent Young Scholars of Shandong Province(ZR2020YQ61,China);Foreign Cultural and Educational Experts Project(GXL20200015001,China);China Postdoctoral Science Foundation(2022M721948);Shandong Province Natural Science Foundation for Youths(ZR2023QH217,China);Natural Science Foundation of Jiangsu Province(BK20230252,China);Qilu Young Scholars Program of Shandong University;Taishan Scholar Program at Shandong Province。
With our continuous endeavors in seeking potent anti-HIV-1 agents,we reported here the discovery,biological characterization,and druggability evaluation of a class of nonnucleoside reverse transcriptase inhibitors.To ...
关键词：HIV-1 Reverse transcriptase Dihydrothiopyrano[3 2-d]pyrimidine Antiviral agent 
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