非侵入性脑刺激技术改善精神分裂症阴性症状的靶点选择及疗效  

Target selection and efficacy of non-invasive brain stimulation techniques in improving negative symptoms of schizophrenia

作　　者：韩云毅 王智民[1] 薄奇静[1] 王传跃[1,2] Han Yunyi;Wang Zhimin;Bo Qijing;Wang Chuanyue(Beijing Anding Hospital,Capital Medical University,National Clinical Research Center for Mental Disorders&National Center for Mental Disorders,Beijing Key Laboratory of Mental Disorders,Beijing 100088,China;Capital Medical University Human Brain Protection Advanced Innovation Center,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京安定医院,国家精神疾病医学中心,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069

出　　处：《中华行为医学与脑科学杂志》2024年第9期855-859,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(81971250);首都卫生发展科研专项项目(首发2022-2-1171)。

摘　　要：精神分裂症的阴性症状对患者的社会功能和生活质量有着深远的影响,而传统治疗手段在改善阴性症状方面效果有限。近年来,重复经颅磁刺激、经颅直流电刺激经颅交流电刺激和经颅随机噪声刺激等非侵入性脑刺激技术在改善阴性症状方面展现出巨大潜力。尽管如此,这些技术的刺激靶点选择仍然是一个需要深入探索的研究领域,不同的靶点可能会导致不同的治疗效果,因此选择更加合适的治疗靶点对阴性症状的改善具有重要意义。本文对不同非侵入性脑刺激技术改善阴性症状研究的靶点选择及治疗效果进行综述,以期对临床治疗中的靶点选择提供参考。Negative symptoms of schizophrenia profoundly affect patients'social function and life quality,and traditional treatments have limited efficacy in improving these symptoms.In recent years,non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation(rTMS),transcranial direct current stimulation(tDCS),transcranial alternating current stimulation(tACS),and transcranial random noise stimulation(tRNS)have shown potentiality in alleviating negative symptoms.However,the selection of stimulation targets remains an area of active research,as different targets may yield varying therapeutic outcomes.Therefore,identifying the most appropriate treatment targets is crucial for improving negative symptoms.This article reviews the targets selection and therapeutic effects of different non-invasive brain stimulation techniques for ameliorating negative symptoms,to provide guidance for target selection in clinical treatment.

关 键 词：精神分裂症 阴性症状 重复经颅磁刺激 经颅直流电刺激 经颅交流电刺激 经颅随机噪声刺激 背外侧前额叶皮质 小脑 背内侧前额叶皮质 

分 类 号：R749.3[医药卫生—神经病学与精神病学]