脂肪肝指数与正常高值血压人群血压转归的相关性研究  

Study on the correlation between fatty liver index and the outcome of high normal blood pressure

作　　者：曲建昌 王安平[2] 窦京涛[2] 谷伟军[2] 吕朝晖[2] 母义明[2] Qu Jianchang;Wang Anping;Dou Jingtao;Gu Weijun;Lyu Zhaohui;Mu Yiming(Department of Endocrinology,the 305th Hospital of PLA,Beijing 100017,China;Department of Endocrinology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军第三〇五医院内分泌科,北京100017 [2]解放军总医院第一医学中心内分泌科,北京100853

出　　处：《中华内科杂志》2024年第10期968-974,共7页Chinese Journal of Internal Medicine

基　　金：解放军第三〇五医院院内基金重点项目(21YNZD01)。

摘　　要：目的分析脂肪肝指数(FLI)与正常高值血压人群血压转归的相关性。方法回顾性队列研究。选取2011年12月至2012年8月进行的中国2型糖尿病患者肿瘤发生风险的流行病学研究(REACTION研究)北京分中心社区居民调查数据。针对其中的正常高值血压人群,获取身高、体重、腰围、空腹血糖、餐后2 h血糖、甘油三酯、高密度脂蛋白胆固醇、γ-谷氨酰转肽酶等指标,并计算FLI,根据FLI水平分为FLI<30组(1822人)、30≤FLI<60组(1026人)和FLI≥60组(473人)。收集2015年4至9月随访调查中该人群的血压转归数据。采用单因素方差分析进行组间比较,采用logistic回归分析FLI与正常高值血压人群血压转归的相关性。结果FLI是总人群以及40岁≤年龄<60岁人群转归为正常血压的独立影响因素(均P<0.01),与FLI<30组相比,在总人群中,30≤FLI<60组及FLI≥60组转归为正常血压的OR值(95%CI)分别为0.63(0.51~0.78)、0.61(0.45~0.82),在40岁≤年龄<60岁人群中OR值(95%CI)分别为0.60(0.47~0.76)和0.57(0.41~0.79);在年龄>60岁人群中,FLI不是转归为正常血压的独立影响因素(P=0.161)。FLI是转归为高血压的独立危险因素(均P<0.05),在总人群、40岁≤年龄<60岁人群、年龄>60岁人群中,30≤FLI<60组和FLI≥60组转归为高血压风险分别为FLI<30组的1.49倍(95%CI 1.23~1.80)和1.54倍(95%CI 1.19~1.98)、1.41倍(95%CI 1.13~1.75)和1.38倍(95%CI 1.04~1.83)、1.75倍(95%CI 1.22~2.53)和2.10倍(95%CI 1.24~3.58)。结论FLI水平与正常高值血压人群转归有相关性,FLI较高者更容易转归为高血压;在40岁≤年龄<60岁人群FLI较高者转归正常血压的可能性较低。Objective To analyze the correlation between fatty liver index(FLI)and the outcomes of individuals with high normal blood pressure.Methods In this retrospective cohort study,data from the follow-up population of the Beijing branch of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal(REACTION)study conducted from December 2011 to August 2012 were selected.Obtain indicators such as height,weight,waist circumference,fasting blood glucose,2-h postprandial blood glucose,triglycerides,high-density lipoprotein cholesterol,and glutamyl transpeptidase were measured,and the FLI was calculated.The population with high normal blood pressure was divided into the FLI<30 group(1822 cases);30≤FLI<60 group(1026 cases);and FLI≥60 group(473 cases)based on FLI levels.The blood pressure outcome data from the follow-up survey of this population from April 2015 to September 2015 were collected.Single factor analysis of variance was used for intergroup comparison,and logistic regression was used to analyze the correlation between FLI and the outcome of high normal blood pressure in the population.Results The FLI was an independent influencing factor for their conversion to normal blood pressure(all P<0.01).Among all observed populations,the likelihood of conversion to normal blood pressure in the 30≤FLI<60 group and FLI≥60 group was 0.63(95%CI 0.51-0.78)and 0.61(95%CI 0.45-0.82)of the FLI<30 group,respectively.In the population of 40≤age<60 years,this likelihood was 0.60(95%CI 0.47-0.76)and 0.57(95%CI 0.41-0.79),respectively.FLI is not an independent influencing factor for the conversion to normal blood pressure in individuals aged over 60 years(P=0.161).FLI is an independent risk factor for hypertension(all P<0.05).Among all observed populations and population of 40≤age<60 years and age>60 years,the risk of hypertension in the 30≤FLI<60 group and FLI≥60 group was 1.49 times(95%CI 1.23-1.80)and 1.54 times(95%CI 1.19-1.98);1.41 times(95%CI 1.13-1.75)and 1.38 times(95%CI 1.04-1.83);and 1.75 time

关 键 词：队列研究 血压 脂肪肝指数 正常高值血压 转归 

分 类 号：R575.5[医药卫生—消化系统]