基于VOSviewer软件探讨中医药治疗小儿抽动-秽语综合征的用药规律  

Exploring the medication patterns of traditional Chinese medicine in treating pediatric Tourette syndrome based on VOSviewer software

作　　者：刘家静 井夫杰[1] LIU Jiajing;JING Fujie(School of Acupuncture-Moxibustion and Tuina,Shandong University of Traditional Chinese Medicine,Jinan,Shandong,250000,China)

机构地区：[1]山东中医药大学针灸推拿学院,山东济南250000

出　　处：《中医儿科杂志》2024年第5期39-45,共7页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：山东省自然科学基金项目(ZR2021MH299);齐鲁医派中医学术流派传承项目(鲁卫函[2022]93号)。

摘　　要：目的检索中国知网(CNKI)、万方数据知识服务平台(Wanfang)、维普中文科技期刊数据库(VIP数据库)、中国生物医学文献服务系统(SinoMed)治疗抽动-秽语综合征(TS)的文献,进行方、药的可视化分析,对中医药治疗小儿TS的用药规律进行全方位探讨,为临床治疗TS提供思路。方法基于文献计量学方法,利用Excel软件对纳入文献中各医家采用的中药自拟方进行拆分、整理,导入至VOSviewer文献可视化软件中,运用频数分析、聚类分析等方法对纳入文献中有关中医用药情况进行数据挖掘。结果390篇非重复文献中涉及处方(自拟方)47张,中药121味,总频数为385次,频数>5次的中药共20味,其中前10味依次为甘草、白芍、僵蚕、钩藤、茯苓、蝉蜕、石菖蒲、龙骨、全蝎、天麻。中药的药性分布中,以寒、平、温使用频数最高;五味分布中,以甘、苦、辛使用频数最高;药物归经依次为肝经、肺经、心经、脾经、肾经、胃经。中药的功效主要为平肝息风、补益、解表、安神,其余药物占比较为平均。对药物特点进行密度视图分析,通过设置药物出现频数(≥3次)得到54味中药的密度图,进一步分析得到A(甘草、白芍、茯苓、钩藤、僵蚕、柴胡、石决明、川芎、龙骨、牡蛎、珍珠母、全蝎)、B(山药、当归、生地黄、熟地黄、枸杞子、山萸肉、泽泻)、C(半夏、陈皮、竹茹、枳实、白术、黄芩、茯神、党参、天竺黄)、D(蝉蜕、玄参、桔梗、薄荷、连翘、牛蒡子、金银花)4组高权重药物。对药物功效进行密度视图分析,得到高权重药物组合为平肝息风药、补益药、化痰药以及清热药。对治疗TS的中药进行聚类分析,通过调整药物的出现频数(≥3次),得到54味中药的聚类视图,依据药物功效以及基本组方思路进行分类,总结得出A(解表热、平肝阳)、B(滋肾阴、补气血、养经筋)、C(补脾虚、疏肝气)、D(息�Objective To conduct a visual analysis of prescriptions and medications for treating Tourette syndrome(TS)through retrieving literature from China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform,VIP Chinese Science and Technology Periodical Database,and SinoMed,and comprehensively explore the medication patterns of traditional Chinese medicine(TCM)in treating pediatric TS,aiming to provide insights for clinical treatment.Methods Based on bibliometric methods,Excel software was used to split and organize the self-made TCM prescriptions adopted by various physicians in the included literature,which were then imported into VOSviewer,a literature visualization software.Frequency analysis,cluster analysis,and other methods were employed to mine the data related to the use of TCM in the included literature.Results Among the 390 non-duplicate articles,47 prescriptions(self-made formulas)and 121 Chinese medicinal materials were involved,with a total frequency of 385 times.A total of 20 medicinal materials were used more than five times,with the top 10 being Glycyrrhiza uralensis Fisch,Paeonia lactiflora Pall.,Bombyx Batryticatus,Ramulus Uncariae cum Uncis,poria cocos,Cryptotympana pustulata Fabricius,Acorus tatarinowii Schott,dragon bone,scorpion,and gastrodia elata in descending order.In terms of medicinal properties,cold,neutral,and warm properties were most frequently used;among the five flavors,sweet,bitter,and pungent flavors were most prevalent.The meridians the medicines entered were mainly liver,lung,heart,spleen,kidney,and stomach meridians.The main effects of the medicines were to calm liver and extinguish wind,nourish and supplement,relieve exterior syndrome,and tranquilize the mind,while the effects of other medicines were relatively evenly distributed.A density view analysis of medicinal characteristics was conducted,and a density map of 54 medicinal materials was obtained by setting the frequency of medicinal appearance(≥3 times).Further analysis yielded four high-weight gr

关 键 词：抽动-秽语综合征 小儿 中医药 用药规律 数据挖掘 

分 类 号：R749.94[医药卫生—神经病学与精神病学]