精氨酸甲基转移酶5在神经系统发育及相关疾病中的功能  

The Role of PRMT5 in Neurodevelopment and Neurological Disorders

作　　者：王雅君 曹建博 何潇潇 WANG Ya-Jun;CAO Jian-Bo;HE Xiao-Xiao(Key Laboratory of Neural Plasticity of Jilin Province,School of Life Science,Northeast Normal University,Changchun 130024,China;School of Life Science,Jilin Agriculture University,Changchun 130118,China;Engineering Laboratory for Brain Cognition and Brain-Inspired Intelligence of Jilin Province,Changchun 130024,China)

机构地区：[1]东北师范大学生命科学学院,吉林省神经可塑性重点实验室,长春130024 [2]吉林农业大学生命科学学院,长春130118 [3]吉林省脑认知与类脑智能工程实验室,长春130024

出　　处：《生理科学进展》2024年第5期415-422,共8页Progress in Physiological Sciences

基　　金：国家自然科学基金(32070809)资助课题。

摘　　要：表观遗传调控在神经系统发育及稳态维持中发挥至关重要的作用。蛋白质精氨酸甲基化是一种在真核细胞中普遍存在的蛋白质翻译后修饰,通过调控组蛋白或非组蛋白的甲基化,来影响细胞中的基因转录调控或RNA剪接等生理事件。本文旨在概述精氨酸甲基转移酶5(protein arginine methyltransferase 5, PRMT5)功能的调控方式,以及其在神经发育环节及神经相关疾病中的多种作用,以探究神经系统中的表观调控机制。Epigenetic regulation plays critical roles in the development and homeostasis of the nervous system.Protein arginine methylation is a post-translational modification commonly found in nearly all eukaryotic cells,which regulates a variety of physiological events,such as gene transcription regulation or RNA splicing,via mediating the methylation of histone or nonhistone targets.This review aims to recapitulate the regulatory mechanism underlying protein arginine methyltransferase 5(PRMT5)function,and summarize the crucial roles of PRMT5 in neural development and neurological diseases,highlighting its epigenetic regulatory mechanism in the nervous system.

关 键 词：表观遗传 精氨酸甲基化 精氨酸甲基转移酶 神经系统发育 神经系统疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]