乳腺组织穿刺活检与定位装置研究进展  

Research progress in breast tissue biopsy and localization devices

作　　者：王紫娟 唐林 李燚 黄小辉 周围[1] 谭米多 WANG Zijuan;TANG Lin;LI Yi;HUANG Xiaohui;ZHOU Wei;TAN Miduo(Department of Breast Surgery,Affiliated Zhuzhou Hospital,Xiangya School of Medicine,Central South University,Zhuzhou Hunan 412000;Department of Anaesthesiology,Affiliated Zhuzhou Hospital,Xiangya School of Medicine,Central South University,Zhuzhou Hunan 412000;Department of General Surgery,Affiliated Zhuzhou Hospital,Xiangya School of Medicine,Central South University,Zhuzhou Hunan 412000,China)

机构地区：[1]中南大学湘雅医学院附属株洲医院乳腺外科,湖南株洲412000 [2]中南大学湘雅医学院附属株洲医院麻醉科,湖南株洲412000 [3]中南大学湘雅医学院附属株洲医院普外科,湖南株洲412000

出　　处：《临床与病理杂志》2024年第6期871-877,共7页Journal of Clinical and Pathological Research

基　　金：湖南省自然科学基金(2024JJ7654)。

摘　　要：乳腺癌是女性高发病率的恶性肿瘤之一。活体组织检查为诊断肿瘤的金标准,组织穿刺活检及定位是早期诊断与精准治疗的重要手段。通过查阅穿刺活检与定位技术,如细针穿刺活检、空芯针穿刺活检、真空辅助抽吸活检、乳腺金属导丝定位系统、放射性粒子定位、乳腺组织定位夹等研究的相关文献,对比现有器械设备,发现其虽各有优点,但均为单一行穿刺或定位的相互独立的器械,无法实现肿瘤穿刺和定位的一体化,尤其是在新辅助化疗后肿瘤缩小或完全消失而失去参照物时。另定位标记夹需专用钛夹钳辅助才能将其置入并固定在原切除肿瘤病灶的周围,这些专用器械未能普及到各种肿瘤手术中,而且价格相对昂贵且易损耗。因此,需在现有设备的基础上进行创新,解决在一次操作中实现组织穿刺活检与定位问题,以减少并发症,降低医疗费用,节约医疗资源,提高患者诊疗舒适度,减轻患者负担,满足肿瘤领域诊治的需求。Breast cancer is one of the most common malignant tumors among women.Pathological examination is the gold standard for tumor diagnosis,and tissue biopsy and localization are crucial for early diagnosis and precise treatment.This paper reviews various biopsy and localization techniques such as fine-needle aspiration biopsy,core needle biopsy,vacuumassisted biopsy,breast metallic wire localization systems,radioactive seed localization,and breast tissue markers.Although these devices have their respective advantages,they are generally independent tools for either biopsy or localization,unable to integrate both functions into a single procedure.This is particularly challenging after neoadjuvant chemotherapy,where the tumor may shrink or disappear,leaving no reference point.Additionally,localization markers require specialized titanium clip forceps for placement and fixation around the original tumor site,but these specialized instruments are not widely available in all tumor surgeries,and they are relatively expensive and prone to wear.Therefore,there is a need for innovation in existing devices to enable the integration of tissue biopsy and localization in a single operation,which could reduce complications,lower medical costs,conserve medical resources,improve patient comfort,alleviate the burden of disease,and meet the diagnostic and treatment needs in the field of oncology.

关 键 词：穿刺活检 乳腺癌 定位 

分 类 号：R737.9[医药卫生—肿瘤]