无创正压呼吸机治疗阻塞性睡眠呼吸暂停综合征对改善阿尔茨海默病血清生物标记物指标与认知功能的效果分析  

Aerobic exercise combined with non-invasive positive pressure ventilation for obstructive sleep apnea significantly reduces major serum biomarkers related to Alzheimer's disease

作　　者：周进[1] 董春瑶[1] 林媛媛[1] 王霞[1] 王旭[1] 杨笑媚 孙迪 王晓蕾[1] 梁丽华 Jin ZHOU;Chunyao DONG;Yuanyuan LIN;Xia WANG;Xu WANG;Xiaomei YANG;Di SUN;Xiaolei WANG;Lihua LIANG(The First People's Hospital of Shenyang,Shenyang 110091,China;Power center hospital in liaoning province,Shenyang 121209,China)

机构地区：[1]沈阳市第一人民医院,沈阳110091 [2]辽宁电力中心医院,沈阳121209

出　　处：《阿尔茨海默病及相关病杂志》2024年第4期277-281,共5页Chinese Journal of Alzheimer's Disease and Related Disorders

摘　　要：目的:了解持续气道正压通气治疗是否可以改善阻塞性睡眠呼吸暂停综合征患者认知功能以及改善阿尔茨海默病重要生物标记物β-淀粉样蛋白1-42/1-40比值。方法:入选阻塞性睡眠呼吸暂停综合征患者56例,采用随机数字表法分为对照组、治疗组各28例。治疗组睡眠过程中给予持续正压无创呼吸机治疗结合有氧运动,对照组仅进行有氧运动,治疗6个月检测血清同型半胱氨酸水平、β-淀粉样蛋白1-42/1-40比值,并使用华山版听觉词语学习测验(auditory verbal learning test-Huashan version,AVLT-H)和动物词语流畅性量表(animal fluency test,AFT)来评估认知功能。结果:治疗6个月时,治疗组血清同型半胱氨酸水平、β-淀粉样蛋白1-42/1-40比值显著低于对照组(P<0.05);AVLT-H即刻回忆评分、AFT评分显著高于对照组(P<0.05)。结论:持续气道正压通气治疗可明显改善阻塞性睡眠呼吸暂停综合征患者的记忆和言语功能,并降低HCY和Aβ_(42)/Aβ_(40)比值,对阻塞性睡眠呼吸暂停综合征的认知障碍可能具有改善作用。Objective:To know the effect of continuous positive airway pressure ventilation on cognitive function and the important biomarker of Alzheimer's disease,β-amyloid protein 1-42/1-40 ratio,in patients with obstructive sleep apnea syndrome.Methods:According to Random Number Table Method,56 patients,being with obstructive sleep apnea syndrome,were randomly divided into the two groups either in treatment group or in control group,as well as each contained 28 cases.In treatment group,continuous positive pressure noninvasive ventilator was used to patients while sleeping at night,and also doing aerobic exercises day time for 3-4 hours per day.In control,only the latter was employed.The serum homocysteine level and theβ-amyloid 1-42 or 1-40 were measured.And the primary results were evaluated using the Huashan version of the Auditory Verbal Learning Test(AVLT-H)and animal fluency test(AFT),which were tested at admission and three months after treatment,respectively.Results:Compared to Control,the serum level of homocysteine andβ-amyloid protein 1-42/1-40 ratio in the treatment group were significantly downregulated by using treatment of continuous positive pressure noninvasive ventilator plus excesses for 3months or 6months(P<0.05),while the AVLT-H immediate recall score and AFT score were significantly upregulated than those in Control(P<0.05).Conclusion:Continuous positive airway pressure therapy can significantly improve memory and speech function in patients with obstructive sleep apnea syndrome,and reduce the HCY and Aβ_(42)/Aβ_(40) ratio,which may have an improving effect on cognitive impairment in obstructive sleep apnea syndrome.

关 键 词：阻塞性睡眠呼吸暂停综合征 持续气道正压通气 认知功能 同型半胱氨酸 血清Aβ42/Aβ40比值 

分 类 号：R74[医药卫生—神经病学与精神病学]