肝脏在阿尔茨海默病发病机制中的作用及干预策略研究进展  

The roles of the liver in the pathogenesis of Alzheimer’s disease and its therapy progress

作　　者：王昊 卢太坤 朱飞奇 Hao WANG;Taikun LU;Feiqi ZHU(Department of Neurology,The First Bethune Hospital of Jilin University,Changchun 130021,Jilin,China;Geriatric cognitive Impairment Ward,Department of Neurology,Shenzhen Luohu District People's Hospital,Shenzhen 518001,Guangdong,China)

机构地区：[1]吉林大学白求恩第一医院神经内科,吉林长春130021 [2]深圳市罗湖区人民医院神经内科老年性认知障碍病房,广东深圳518001

出　　处：《阿尔茨海默病及相关病杂志》2024年第4期297-303,共7页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：深圳市医疗卫生三名工程项目“瑞典卡罗琳斯卡医学院NVS系Bengt Winblad教授阿尔茨海默病团队”(SZSM201801014);深圳市科创委重点项目“AD前期及患者健康管理大数据构建及其预测预警模型研究”(JCYJ20200109143431341)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是最常见的老年期痴呆类型,主要发病机制包括大脑Aβ沉积、tau蛋白过度磷酸化、神经炎症、神经元氧化应激、脑微循环障碍等。近些年越来越多的研究发现肝脏与AD发病密切相关,肝脏不仅是外周清除Aβ的主要器官,还能通过多种途径影响大脑的AD病理改变,包括认知、情绪、脑灌注和脑代谢。本文对肝脏参与AD发病机制和治疗的研究进行阐述,期望从干预肝脏疾病的角度寻找更有效的AD治疗方法。Alzheimer's disease(AD)is the most common type of dementia in the elderly.The main pathogenesis of AD includes brain Aβdeposition,tau protein hyperphosphorylation,neuroinflammation,neuronal oxidative stress,and cerebral microcirculation disorders.In recent years,increasing evidence suggests that the liver is closely related to the pathogenesis of AD.The liver is not only the main organ for peripheral Aβclearance,but also can affect the pathological changes of AD in the brain through a variety of ways,including cognition,emotion,cerebral perfusion and brain metabolism.This article summarizes the research on the liver's roles in the pathogenesis and treatment of AD,hoping to find more effective treatment methods for AD from the perspective of liver intervention.

关 键 词：阿尔茨海默病 肝脏疾病 Β-淀粉样蛋白 肝-脑轴 肝酶 

分 类 号：R74[医药卫生—神经病学与精神病学]