可控的响应性一氧化氮纳米递送系统在肿瘤治疗中的研究进展  

Research Progress of Controllable and Responsive Nitric Oxide Nanodelivery Systems in Tumor Therapy

作　　者：柳超[1] 唐小慧 李莎莎 陈建军[1] LIU Chao;TANG Xiaohui;LI Shasha;CHEN Jianjun(School of Medical Engineering and Technology,Xinjiang Medical University,Urumqi 830017;Core Facility,Xinjiang Medical University,Urumqi 830017;School of Pharmacy,Xinjiang Medical University,Urumqi 830017)

机构地区：[1]新疆医科大学医学工程技术学院,新疆乌鲁木齐830017 [2]新疆医科大学中心实验室,新疆乌鲁木齐830017 [3]新疆医科大学药学院,新疆乌鲁木齐830017

出　　处：《中国医药工业杂志》2024年第9期1171-1178,共8页Chinese Journal of Pharmaceuticals

基　　金：新疆维吾尔自治区自然科学基金(2021D01C279)。

摘　　要：一氧化氮作为一种内源性信使分子,在肿瘤治疗中具有多重功效,不仅能够引起肿瘤细胞凋亡,还能与其他治疗方式实现较好的协同作用。为提高其治疗效率,研究工作者们设计、制备了各种类型的一氧化氮纳米递送系统并用于肿瘤治疗研究。其中,可控的响应性一氧化氮纳米递送系统以其出色的按需释放能力和优异的疗效受到了广泛关注。本文主要综述了基于不同纳米材料的可控、响应性一氧化氮纳米递送系统,并分别从内源性和外源性刺激响应功能讨论其在肿瘤治疗中的应用,以期为一氧化氮纳米递送系统的进一步发展提供参考。As an endogenous messenger molecule,nitric oxide has multiple effects in tumor treatment.It can not only induce tumor cell apoptosis but also achieve outstanding synergy with other treatment methods.To improve its therapeutic efficiency,researchers have designed and prepared various types of nitric oxide nanodelivery systems and applied to tumor therapy research.Among them,the controllable responsive nitric oxide nanodelivery systems have received extensive attention for their excellent on-demand release ability and brilliant therapeutic effect.This article mainly reviews the controllable responsive nitric oxide nanodelivery systems based on different nanomaterials and discusses their applications in tumor therapy from endogenous-based and exogenous-based stimuli-responsiveness respectively,in order to provide a reference for the further development of nitric oxide nanodelivery systems.

关 键 词：一氧化氮 纳米递送系统 响应性 肿瘤治疗 研究进展 

分 类 号：R730.5[医药卫生—肿瘤] R944.9[医药卫生—临床医学]