光动力疗法辅助牙周正畸治疗对牙周炎患者症状改善、炎症反应及牙周菌群的影响  

Effects of photodynamic therapy assisted periodontal orthodontic treatment on symptom improvement,inflammatory response and periodontal flora in patients with periodontitis

作　　者：来莉 傅超 LAI Li;FU Chao(Xi'an Chang'an District Hospital,Xi'an 710118,China)

机构地区：[1]西安市长安区医院,陕西西安710118

出　　处：《临床医学研究与实践》2024年第29期103-106,共4页Clinical Research and Practice

摘　　要：目的分析光动力疗法(PDT)辅助牙周正畸治疗对牙周炎患者症状改善、炎症反应及牙周菌群的影响。方法将2021年1月至12月于我院行牙周正畸治疗的100例牙周炎患者纳入本次研究,以牙周正畸辅助治疗方案差异将其分为正畸组和PDT组,各50例。正畸组给予牙周正畸常规辅助治疗,PDT组在正畸组治疗的基础上增加PDT辅助治疗。比较两组的治疗效果。结果PDT组的治疗总有效率高于正畸组(P<0.05)。治疗后,PDT组的牙龈指数(GI)、探诊深度(PD)、菌斑指数(PLI)及附着丧失(AL)均显著低于正畸组(P<0.05)。治疗后,PDT组的单核细胞趋化蛋白-1(MCP-1)、可溶性细胞间黏附分子-1(sICAM-1)与金属基质蛋白酶-9(MMP-9)水平均低于正畸组,α-羟丁酸脱氢酶(HBD)水平高于正畸组(P<0.05)。治疗后,PDT组的牙龈卟啉单胞菌、中间拟杆菌及坏死梭杆菌数量低于正畸组(P<0.05)。结论PDT辅助牙周正畸治疗牙周炎患者可取得理想疗效。Objective To analyze the effects of photodynamic therapy(PDT)assisted periodontal orthodontic treatment on symptom improvement,inflammatory response and periodontal flora in patients with periodontitis.Methods A total of 100 patients with periodontitis who underwent periodontal orthodontic treatment in our hospital from January to December 2021 were included in this study.The patients were divided into orthodontic group and PDT group according to the difference of periodontal orthodontic adjuvant treatment plans,with 50 cases in each group.The orthodontic group was given routine adjuvant therapy of periodontal orthodontics,and the PDT group was given PDT adjuvant therapy on the basis of the orthodontic group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the PDT group was higher than that in the orthodontic group(P<0.05).After treatment,the gingival index(GI),probing depth(PD),plaque index(PLI)and attachment loss(AL)in the PDT group were significantly lower than those in the orthodontic group(P<0.05).After treatment,the levels of monocyte chemoattractant protein-1(MCP-1),soluble intercellular adhesion molecule-1(sICAM-1)and matrix metalloprotein-9(MMP-9)in the PDT group were lower than those in the orthodontic group,and the level ofα-hydroxybutyricacid dehydrogenase(HBD)was higher than that in the orthodontic group(P<0.05).After treatment,the number of Porphyromonas gingivalis,Bacteroides intermedia and Clostridium necrosis in the PDT group were lower than those in the orthodontic group(P<0.05).Conclusion PDT assisted periodontal orthodontic treatment can achieve ideal results in patients with periodontitis.

关 键 词：牙周炎 光动力疗法 牙周正畸 炎症指标 牙周菌群 

分 类 号：R783.5[医药卫生—口腔医学]