乳腺癌组织内VEGF-C、HIF-1α表达与血管生成的相关性研究  

Correlation between the Expression of VEGF-C,HIF-1αand Angiogenesis in Breast Cancer Tissues

作　　者：刘焱[1] 宋璐 林敏[1] LIU Yan;SONG Lu;LIN Min(Tai’an Central Hospital,Tai’an 271000,China;不详)

机构地区：[1]泰安市中心医院,山东泰安271000

出　　处：《中外医学研究》2024年第28期73-77,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：山东省自然科学基金资助项目(ZR2016HB48)。

摘　　要：目的:探讨乳腺癌患者组织内血管内皮生长因子-C(VEGF-C)、缺氧诱导因子-1α(HIF-1α)表达与血管生成的关系。方法:选取2022年1月—2023年12月泰安市中心医院收治的198例乳腺癌女性患者,并选取同期经病理学检查为乳腺纤维瘤患者50例为对照。采用免疫组化S-P法检测乳腺癌和乳腺纤维瘤组织中VEGF-C、HIF-1α表达及微血管密度(MVD)数,分析VEGF-C、HIF-1α表达与临床病理特征及MVD的关系。结果:乳腺癌患者乳腺组织中VEGF-C、HIF-1α阳性表达率及MVD数均高于乳腺纤维瘤患者,差异有统计学意义(P<0.05)。VEGF-C阳性与阴性表达者年龄、肿瘤直径、组织学分级、ER表达、PR表达等临床病理特征比较,差异无统计学意义(P>0.05);VEGF-C阳性表达者有淋巴结转移、TNM分期为Ⅲ~Ⅳ期、分子分型(Luminal B、HER-2阳性、基底细胞)的患者占比及MVD均高于VEGF-C阴性表达者,差异有统计学意义(P<0.05)。HIF-1α阳性与阴性表达者年龄、肿瘤直径、ER表达、PR表达、分子分型等临床病理特征比较,差异无统计学意义(P>0.05);HIF-1α阳性表达者组织学分级为Ⅱ级、Ⅲ级、有淋巴结转移、TNM分期为Ⅲ~Ⅳ期的患者占比及MVD均高于HIF-1α阴性表达者,差异有统计学意义(P<0.05)。结论:乳腺癌患者组织内VEGF-C、HIF-1α阳性表达率明显升高,并且还与肿瘤血管生成存在显著相关性。Objective:To investigate the relationship between the expression of vascular endothelial growth factor-C(VEGF-C),hypoxia inducible factor-1α(HIF-1α)and angiogenesis in breast cancer tissues.Method:A total of 198 female patients with breast cancer admitted to Tai’an Central Hospital from January 2022 to December 2023 were selected,and 50 patients with breast fibroma diagnosed pathologically in the same period were selected as controls.Immunohistochemical S-P method was used to detect the expression of VEGF-C,HIF-1αand microvessel density(MVD)in breast cancer and breast fibroma.The relationship between the expression of Changes in IgE sensitization and total IgE levels over 20 years of VEGF-C,HIF-1αand clinicopathological features and MVD were analyzed.Result:The positive expression rate of VEGF-C and HIF-1αand the number of MVD in breast tissue of breast cancer patients were higher than those of breast fibroma patients,and the differences were statistically significant(P<0.05).There were no significant differences in clinical pathological characteristics such as age,tumor diameter,histological grading,ER expression,PR expression between VEGF-C positive and negative expression patients(P>0.05);the proportion of patients with lymph node metastasis,TNM stageⅢ-Ⅳ,molecular typing(Luminal B,HER-2 positive,basal cell),and MVD were higher in patients with positive expression of VEGF-C than in those with negative expression of VEGF-C,the differences were statistically significant(P<0.05).There were no significant differences in clinical pathological characteristics such as age,tumor diameter,ER expression,PR expression,and molecular typing between HIF-1αpositive and negative expression patients(P>0.05);the proportion of patients with histological grading of gradeⅡ-Ⅲ,lymph node metastasis,and TNM stageⅢ-Ⅳ,as well as the number of MVD in HIF1αpositive expression patients were higher than in HIF-1αnegative expression patients,the differences were statistically significant(P<0.05).Conclusion:The positive

关 键 词：乳腺癌 血管内皮生长因子 -C 缺氧诱导因子 -1α 临床病理特征 微血管密度 

分 类 号：R737.9[医药卫生—肿瘤]