血清HSP90α联合lncRNA SNHG5与常规血清肿瘤标志物诊断早期结直肠癌的价值  

Value of serum HSP90αcombined with lncRNA SNHG5 and conventional serum tumor markers in the diagnosis of early colorectal cancer

作　　者：徐菱遥 江南 赵俊波 魏书堂[1] XU Ling-yao;JIANG Nan;ZHAO Jun-bo;WEI Shu-tang(Hospital of Gastroenterology,the First Affiliated Hospital of Henan University,Kaifeng 475000,Henan,CHINA)

机构地区：[1]河南大学第一附属医院消化病医院,河南开封475000

出　　处：《海南医学》2024年第19期2792-2797,共6页Hainan Medical Journal

基　　金：2023年度河南省开封市科技发展计划项目(编号:2303015)。

摘　　要：目的比较血清热休克蛋白90α(HSP90α)联合清长链非编码RNA小核仁RNA宿主基因5(lncRNA SNHG5)和常规血清肿瘤标志物诊断早期结直肠癌(CRC)的临床应用价值。方法采用倾向性评分匹配法和1∶1∶1原则选取2021年3月至2024年4月河南大学第一附属医院收治的215例早期CRC患者(肠癌组)、215例结直肠良性病变患者(良性组)和215例健康体检人群(对照组)作为研究对象。比较三组受检者常规血清肿瘤标志物[癌胚抗原(CEA)、糖类抗原(CA)199、CA242、CA724、CA153、CA50、CA125]、血清HSP90α、lncRNA SNHG5水平,采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析常规血清肿瘤标志物、血清HSP90α、lnc RNA SNHG5诊断早期CRC的价值,并比较不同方案的诊断效能。结果肠癌组患者的CEA、CA199、CA242、CA724、CA153、CA50、CA125分别为(5.32±1.76)ng/mL、(32.98±10.89)U/mL、(16.19±5.38)U/mL、(8.30±2.72)U/mL、(20.43±6.80)U/mL、(23.79±7.91)U/mL、(40.57±13.25)U/mL,良性组分别为(2.91±0.94)ng/mL、(13.60±4.17)U/mL、(4.79±1.58)U/mL、(3.94±1.00)U/mL、(11.02±3.57)U/mL、(4.46±1.39)U/mL、(40.57±13.25)U/mL,对照组分别为(2.60±0.81)ng/mL、(12.84±3.95)U/mL、(4.25±1.86)U/mL、(3.59±1.16)U/mL、(10.86±3.49)U/mL、(4.15±1.28)U/mL、(14.99±4.95)U/mL,肠癌组患者的上述各项指标明显高于良性组和对照组,差异均有统计学意义(P<0.05),良性组与对照组比较差异均无统计学意义(P>0.05);肠癌组患者的HSP90α、lncRNA SNHG5分别为(34.69±11.50)U/mL、2.84±0.93,良性组分别为(15.30±3.49)ng/L、1.95±0.67,对照组分别为(11.57±2.36)ng/L、1.86±0.51,肠癌组患者的上述各项指标明显高于良性组和对照组,差异均有统计学意义(P<0.05),良性组患者的血清HSP90α水平明显高于对照组,差异均有统计学意义(P<0.05),但良性组和对照组的血清lncRNA SNHG5水平比较差异无统计学意义(P>0.05);ROC分析结果显示,常规血清肿瘤标志物诊断早期CRC的Objective To compare the clinical application value of heat shock protein 90α(HSP90α)combined with long non-coding RNA small nucleolar RNA host gene 5(lncRNA SNHG5)and conventional serum tumor markers for the diagnosis of early colorectal cancer(CRC).Methods Using propensity score matching and 1:1:1 principle,215 patients with early CRC(CRC group),215 patients with benign colorectal lesions(benign group),and 215 healthy individuals(control group)at the First Affiliated Hospital of Henan University from March 2021 to April 2024 were selected as study subjects.The levels of routine serum tumor markers(carcinoembryonic antigen[CEA],carbohydrate antigen[CA]199,CA242,CA724,CA153,CA50,CA125),serum HSP90α,and lncRNA SNHG5 were compared among the three groups of subjects.The diagnostic value of routine serum tumor markers,serum HSP90α,and lncRNA SNHG5 for the diagnosis of early CRC was analyzed using receiver operating characteristic(ROC)curves and area under the curve(AUC),and the diagnostic efficacy of different schemes was compared.Results The CEA,CA199,CA242,CA724,CA153,CA50,and CA125 levels were(5.32±1.76)ng/mL,(32.98±10.89)U/mL,(16.19±5.38)U/mL,(8.30±2.72)U/mL,(20.43±6.80)U/mL,(23.79±7.91)U/mL,and(40.57±13.25)U/mL in the intestinal cancer group,respectively;(2.91±0.94)ng/mL,(13.60±4.17)U/mL,(4.79±1.58)U/mL,(3.94±1.00)U/mL,(11.02±3.57)U/mL,(4.46±1.39)U/mL,and(40.57±13.25)U/mL in the benign group;(2.60±0.81)ng/mL,(12.84±3.95)U/mL,(4.25±1.86)U/mL,(3.59±1.16)U/mL,(10.86±3.49)U/mL,(4.15±1.28)U/mL,and(14.99±4.95)U/mL in the control group.The levels of the above indicators in the intestinal cancer group were significantly higher than those in the benign group and control group(P<0.05).There was no statistically significant difference in the above indicators between the benign group and control group(P>0.05).The HSP90αand lncRNA SNHG5 levels were(34.69±11.50)U/mL and 2.84±0.93 in the intestinal cancer group,(15.30±3.49)ng/L and 1.95±0.67 in the benign group,and(11.57±2.36)ng/L and(1.86±0.51)

关 键 词：结直肠癌 热休克蛋白90Α 长链非编码RNA 小核仁RNA宿主基因5 肿瘤标志物 诊断 

分 类 号：R735[医药卫生—肿瘤]