Effect of Elevated Temperatures on Inflammatory Cytokine Release:An In Vitro and Population-Based Study  

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作  者:Xiaoxu Hu Hualing Fu Luou Zhang Qian Zhang Tong Xu Yangsheng Chen Guomin Chen Shuai Jiang Jiajia Ji Heidi Qunhui Xie Li Xu Bin Zhao 

机构地区:[1]Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China [4]Jinbo Bio-Pharmaceutical Co,LTD,Taiyuan 300032 Shanxi,China [5]Department of Cardiology,Beijing Hospital,National Center of Gerontology,Beijing 100730,China [6]Environment and Health Department,Shenzhen Center for Disease Control and Prevention,Shenzhen 518055 Guangdong,China [7]School of Environment,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

出  处:《Environment & Health》2024年第10期721-728,共8页环境与健康(英文)

基  金:supported by the National Natural Science Foundation of China(No.22076216);the National Key Research and Development Program of China(2018YFA0901100);Sanming Project of Medicine in Shenzhen(SZSM201811070);Shenzhen Key Medical Discipline Construction Fund(SZXK067).

摘  要:Extreme high temperatures in the summer have become a global concern,and their risks to the inflammatory system have been largely unknown.Here we appraised the exposure risks of summer heatwaves by comparing the sera cytokine levels in healthy individuals under high and normal temperatures.In addition,we established a cell model with a 1.5°C temperature increase to investigate the regulatory mechanisms of temperature-related cytokines.Our results suggest that elevated temperatures enhance the release of interleukin-6(IL-6)and interleukin-8(IL-8)via the aryl hydrocarbon receptor(AhR)pathway and augment the proinflammatory effects of other factors.This suggests that we may have underestimated the impact of high temperatures on the health of individuals beyond just mortality rates.Moreover,seemingly minor temperature increases of just 1.5℃ can still pose a challenge to cells.

关 键 词:global warming heatwaves INFLAMMATION aryl hydrocarbon receptor INTERLEUKIN-6 INTERLEUKIN-8 

分 类 号:R122[医药卫生—环境卫生学]

 

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