Prenatal Environmental Antibiotic Exposure and Autism Spectrum Disorder Symptoms in Children at 3 Years of Age:Findings from the Ma’anshan Birth Cohort Study  

作　　者：Baolin Wang Feifei Han Peng Ding Juan Tong Kaiyong Liu Shuangqin Yan Sheng Wang Guanjun Chen Xiaoyan Wu Kun Huang Menglong Geng Fangbiao Tao 

机构地区：[1]School of Public Health,Anhui Medical University,Hefei 230032 Anhui,China [2]Key Laboratory of Population Health Across Life Cycle(Anhui Medical University),Ministry of Education of the People’s Republic of China,Hefei 230032 Anhui,China [3]NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University),Hefei 230032 Anhui,China [4]Anhui Provincial Key Laboratory of Environment and Population Health across the Life Course,Anhui Medical University,Hefei 230032 Anhui,China [5]Ma’anshan Maternal and Child Healthcare(MCH)Center,Ma’anshan 243011,China [6]The Center for Scientific Research of Anhui Medical University,Anhui Medical University,Hefei 230032 Anhui,China

出　　处：《Environment & Health》2024年第9期651-660,共10页环境与健康（英文）

基　　金：supported by the National Natural Science Foundation of China(NSCF-82204053);the University Natural Foundation of Anhui Educational Committee(KJ2021A0222);the National Key Research and Development Program of China(2016YFC1000204-2);the Discipline Construction Project of School of Public Health,Anhui Medical University(0301001872).

摘　　要：ABSTRACT:Antibiotic exposure during pregnancy may affect the neurodevelopment of children,but biomonitoring-based population studies on this class of new pollutants are lacking.We conducted a prospective birth cohort study of 2860 mother−child pairs,measured the urinary concentrations of 41 antibiotics and their two metabolites over three trimesters,and assessed children’s autism spectrum disorder(ASD)symptoms at 3 years of age.We examined the associations between prenatal antibiotic exposure and children’s ASD symptoms.The least absolute shrinkage and selection operator regression screened for Tetracycline and Ofloxacin as important predictors of ASD symptoms.Modified Poisson regression models revealed that maternal Tetracycline exposure throughout pregnancy increased the risk of ASD symptoms(RR:1.66,95%CI:1.14,2.40).Maternal Tetracycline exposure during the first(RR:1.74,95%CI:1.13,2.68)and third trimesters(RR:1.86,95%CI:1.16,3.00)increased the risk of ASD symptoms in boys,and Ofloxacin exposure during the first trimester(RR:1.47,95%CI:1.07,2.02)increased the risk of ASD symptoms in girls.No dose-dependent relationships between prenatal antibiotic exposure and ASD symptoms were validated by restricted cubic splines.Prenatal exposure to Tetracycline and Ofloxacin may increase the risk of ASD symptoms in children,and the first and third trimesters might be the key windows.

关 键 词：ANTIBIOTICS BIOMONITORING Urine biomarkers Prenatal exposure AUTISM Birth cohort 

分 类 号：R749[医药卫生—神经病学与精神病学]