Insights into Triclosan-Induced Endocrine Disruption:Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models  

作　　者：Zhiming Li Hongyi Xian Xiaohu Ren Rongyi Ye Yizhou Zhong Yuji Huang Boxuan Liang Yanhong Deng Mingzhu Dai Jie Guo Shuqin Tang Jialiang Pan Yu Feng Ruobing Bai Xueping Chen Sahoko Ichihara Gaku Ichihara Da Chen Xingfen Yang Zhenlie Huang 

机构地区：[1]NMPA Key Laboratory for Safety Evaluation of Cosmetics,Guangdong Provincial Key Laboratory of Tropical Disease Research,Department of Toxicology,School of Public Health,Southern Medical University,Guangzhou 510515,China [2]Shenzhen Key Laboratory of Modern Toxicology,Shenzhen Medical Key Discipline of Health Toxicology,Shenzhen Center for Disease Control and Prevention,Shenzhen 518055,China [3]Hunter Biotechnology,Inc.,Hangzhou 310051,China [4]College of Environment and Climate,Guangdong Provincial Key Laboratory of Environmental Pollution and Health,Jinan University,Guangzhou 510632,China [5]Vitargent(International)Biotechnology Limited,Shatin 999077,Hong Kong SAR,China [6]Department of Environmental and Preventive Medicine,School of Medicine,Jichi Medical University,Tochigi 329-0498,Japan [7]Department of Occupational and Environmental Health,Faculty of Pharmaceutical Sciences,Tokyo University of Science,Noda 278-8510,Japan

出　　处：《Environment & Health》2024年第7期424-440,共17页环境与健康（英文）

基　　金：Science and Technology Project of Guangdong Province,China(2022A0505050035);National Natural Science Foundation of China(82273656,82304177,82073519);Guangdong Basic Applied Basic Research Foundation(2022A1515010610,Guangdong-Dongguan Joint grant 2022A1515111098,Guangdong-Guangzhou Joint grant 2023A1515110373);Chinese Postdoctoral Science Foundation(2023M741553,2022M721486,2023T160295);Postdoctoral Fellowship Program of CPSF(GZC20231055);National Training Program of Innovation and Entrepreneurship for Undergraduates(202212121034,S202312121124);Guangdong Provincial Key Laboratory of Tropical Disease Research(2017B030314035);NMPA Key Laboratory for Safety Evaluation of Cosmetics,and the GDMPA Project of Scientific and Technological Innovation(2024ZDZ09).

摘　　要：Triclosan(TCS)has garnered significant attention due to its widespread use and associated endocrine-disrupting effects.However,its impact on the neuroendocrine system and underlying mechanisms remain poorly understood.Here,we established correlations between TCS exposure and serum sex hormone levels in participants of the National Health and Nutrition Examination Survey(NHANES).Additionally,we investigated TCS’s influence on the neuroendocrine system using adult zebrafish exposed to environmentally relevant concentrations of TCS(0.361–48.2μg/L)for 21 days.Assessment of reproductive and neurotoxicity included histopathological examination and behavioral tests.Transcriptomics,proteomics analyses,and biochemical detection were employed to elucidate mechanisms underlying TCS-induced neuroendocrine disruption.Significant correlations were found between TCS exposure and estradiol,testosterone,and sex hormone-binding globulin levels in NHANES participants.In addition,TCS exposure inhibited ovary development and spermatogenesis in zebrafish.Transcriptomics and proteomics analysis revealed gender-specific key signaling and metabolism-related pathways implicated in TCS-induced reproductive toxicity.Moreover,TCS exposure induced nervous system impairment,as evidenced by histological changes and altered motor behavior,possibly associated with oxidative damage.Correlation analysis further highlighted the potential connection between endocrine system disruption and nervous system impairment following TCS exposure.Overall,this study provided evidence supporting TCS-induced endocrine disruption and offered insights into its underlying mechanisms.

关 键 词：Emerging Contaminants ECOTOXICITY Public Health Endocrine-Disrupting Chemicals Endocrine-Disrupting Effects 

分 类 号：X171[环境科学与工程—环境科学]