膳食炎症指数与血清C反应蛋白关联性的Meta分析  

Association between dietary inflammation index and serum C reactive protein level:a Meta-analysis

作　　者：马润泽 巴合古·依明尼亚孜 顾园申 赵辉 阿娜尔·高少 余文慧 戴江红[1] MA Runze;BAHEGU Yimingniyazi;GU Yuanshen;ZHAO Hui;ANAER Gaoshao;YU Wenhui;DAI Jianghong(School of Public Health,Xinjiang Medical University,Urumqi 830017,China)

机构地区：[1]新疆医科大学公共卫生学院,乌鲁木齐830017

出　　处：《中华疾病控制杂志》2024年第9期1104-1111,共8页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(82360662,82160640);科技创新团队“天山创新团队”项目(2022TSYCTD0013)。

摘　　要：目的系统评价膳食炎症指数(dietary inflammatory index,DII)与血清C反应蛋白(C-reactive protein,CRP)的关联性。方法检索PubMed、Web of Science和EMBASE数据库,收集有关DII与CRP关联性研究资料,检索时限从建库至2023年10月1日。由两名独立研究者进行文献筛选、数据提取、质量评价,采用R 4.2.2软件进行统计分析,并利用亚组分析、Meta回归分析探索异质性来源。结果共纳入20项研究,其中包括15项横断面研究、1项病例对照研究、3项队列研究、1项随机对照试验,累计纳入研究对象59953例。Meta回归分析结果显示,DII与血清CRP水平相关(OR=1.205,95%CI:1.101~1.319)。通过基于研究类型、年龄分布、样本量、DII与膳食调查方法的亚组分析后,I2降低(P>0.1)。结论DII与血清CRP水平相关。研究类型、年龄分布、样本量、DII与膳食调查方法的不同可能是影响各研究间异质性的主要因素。Objective To systematically evaluate the association between the dietary inflammatory index(DII)and serum C-reactive protein(CRP)levels.Methods A search of the PubMed,Web of Science,and EMBASE databases was conducted to collect studies examining the association between the DII and CRP.The search period extended from the inception of each database until October 1,2023.Two independent researchers performed the literature screening,data extraction,and quality assessment.Statistical analyses were conducted using R software version 4.2.2,and subgroup analyses and Meta-regression were utilized to explore the sources of heterogeneity among studies.Results A total of 20 studies were included,comprising 15 cross-sectional studies,1 case-control study,3 cohort studies,and 1 randomized controlled trial,with a cumulative total of 59953 participants.The Meta-analysis indicated a significant association between the DII and serum CRP levels(OR=1.205,95%CI:1.101~1.319).After conducting subgroup analyses based on study design,age distribution,sample size,DII calculation methods,and dietary assessment techniques,the I2 statistic was reduced(P>0.1).Conclusions Current evidence suggests that the DII may be associated with serum CRP levels.Differences in study design,age distribution,sample size,DII calculation methods,and dietary assessment techniques may be the primary factors contributing to the heterogeneity observed among the studies.

关 键 词：膳食炎症指数 C反应蛋白 META分析 慢性低度炎症 

分 类 号：R151[医药卫生—营养与食品卫生学] R181[医药卫生—公共卫生与预防医学]