青年与老年胶质母细胞瘤患者的临床与免疫特征差异  

Differences in clinical and immune characteristics between young and elderly glioblastoma patients

作　　者：王秉恒 季楠[1] WANG Bingheng;JI Nan(Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院神经外科,北京100070

出　　处：《临床神经外科杂志》2024年第5期495-500,共6页Journal of Clinical Neurosurgery

基　　金：首都卫生发展科研专项项目(首发202222047)。

摘　　要：目的通过分析青年与老年胶质母细胞瘤(GBM)患者临床和免疫特征,对比青年与老年GBM患者临床病理、预后差异及肿瘤免疫浸润差异。方法回顾性分析2022年1月-2024年6月在北京天坛医院接受手术治疗的447例GBM患者临床资料,应用CGGA和TCGA数据库对青年GBM和老年GBM患者的RNA-seq数据进行预后及免疫特征分析。结果在临床特征上,青年GBM患者与老年GBM患者在性别、MGMT甲基化、TERT突变、EGFR扩增以及TP53突变均表现出差异,而在肿瘤发生位置、左右侧别、肿瘤直径大小及免疫组化中Ki-67无明显差异。青年GBM患者的总生存期显著长于老年GBM患者。免疫方面,老年GBM患者整体表现出更明显的免疫抑制性微环境特征。结论青年GBM患者较老年GBM患者生存期较长,预后较好,且青年与老年GBM患者在临床病理特征和免疫微环境方面存在明显差异。Objective To compare the differences in clinical pathological feature,prognosis and immune characteristics between elderly and young patients by analyzing the clinical and pathological features of young and elderly glioblastoma(GBM)patients.Methods The clinical data of 447 GBM patients who underwent surgical treatment at Beijing Tiantan Hospital from January 2022 to June 2024 were analyzed retrospectively.Prognostic and immunological of RNA-seq data from young and elderly GBM patients were analyzed by using CGGA and TCGA databases.Results For the part of clinical characteristics,young GBM patients and elderly GBM patients showed differences in gender,MGMT methylation,TERT mutation,EGFR amplification,and TP53 mutation,while there were no significant differences in tumor location,side,size and immunohistochemistry of Ki-67.The overall survival(OS)of young GBM patients was significantly longer than that of elderly GBM patients.In terms of immunity,elderly patients showed more obvious characteristics of immunosuppressive microenvironment.Conclusions Young GBM patients have longer survival time and better prognosis than elderly GBM patients,and there are significant differences in clinicopathological features and immune microenvironment between young and elderly GBM patients.

关 键 词：青年胶质母细胞瘤 老年胶质母细胞瘤 临床特征 免疫微环境 

分 类 号：R739.41[医药卫生—肿瘤]