Mechanisms of tigecycline resistance in Gram-negative bacteria:A narrative review  

作　　者：Wenya Su Wenjia Wang Ling Li Mengge Zhang Hai Xu Chengzhang Fu Xiuhua Pang Mingyu Wang 

机构地区：[1]State Key Laboratory of Microbial Technology,Microbial Technology Institute,Shandong University,Qingdao 266237,PR China [2]Helmholtz Institute for Pharmaceutical Research Saarland(HIPS),Helmholtz Centre for Infection Research(HZI),and Department of Pharmacy,Saarland University,Saarbrücken 66123,Germany

出　　处：《Engineering Microbiology》2024年第3期54-61,共8页工程微生物学（英文）

基　　金：supported by the National Key Research and De-velopment Program of China[grant number 2022YFE0199800];Key R&D Program of Shandong Province[grant number 2020CXGC011305];Shandong Provincial Natural Science Foundation[grant number ZR2020MH308];the National Natural Science Foundation of China[grant number 82,271,658].

摘　　要：Tigecycline serves as a critical“final-resort”antibiotic for treating bacterial infections caused by multidrug-resistant bacteria for which treatment options are severely limited.The increasing prevalence of tigecycline resistance,particularly among Gram-negative bacteria,is a major concern.Various mechanisms have been iden-tified as contributors to tigecycline resistance,including upregulation of nonspecific Resistance Nodulation Divi-sion(RND)efflux pumps due to mutations in transcriptional regulators,enzymatic modification of tigecycline by monooxygenase enzymes,and mutations affecting tigecycline binding sites.This review aims to consolidate our understanding of tigecycline resistance mechanisms in Gram-negative bacteria and offer insights and perspectives for further drug development.

关 键 词：Gram-negative bacteria TIGECYCLINE Tigecycline resistance Resistance mechanisms RND efflux pump 

分 类 号：Q93[生物学—微生物学]