Nickel/Photoredox Dual Catalytic Chan-Lam Coupling of Aryl Azides and Arylboric Acids  

作　　者：Xia Ge Haojie Ji Hongjian Lu 

机构地区：[1]Schoolof Chemistry and Chemical Engineering,Nanjing University,Nanjing,Jiangsu 210093,China

出　　处：《Chinese Journal of Chemistry》2024年第18期2228-2234,共7页中国化学（英文版）

基　　金：financial support by the National National Natural Science Foundation of China(22271148,22071100).

摘　　要：Unsymmetrical diarylamines are crucial components in many pharmaceuticals and functional materials.In this study,we introduce an efficient Chan-Lam cross-coupling method that utilizes phenylboronic acids and aryl azides as coupling agents in a redox-neutral environment,enabled by a synergistic nickel/photoredox catalytic system.This approach leverages a proton-coupled electron transfer mechanism to bypass the typical nitrene pathway associated with aryl azides,which is prone to intramolecular rearrangement,C-H amination,and reductive hydrogenation.Notably,our method exhibits broad compatibility with a variety of functional groups,including those derived from pharmaceuticals,demonstrating its versatile potential in organic synthesis and drug modification.

关 键 词：AZIDES Chan-Lam reaction NICKEL Iridium Redox-neutral PHOTOCHEMISTRY 

分 类 号：O62[理学—有机化学]