Pd-Catalyzed Dienylation of Propargylic Esters Enabling Highly Stereoselective Synthesis of Danishefsky-Type Trisubstituted Dienes  

作　　者：Chen Zhou Mengfu Dai Xiaoyu Yin Mingyue Zhang Weijin Gu Liang-An Chen 

机构地区：[1]Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of New Power Batteries,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing,Jiangsu 210023,China

出　　处：《Chinese Journal of Chemistry》2024年第17期1993-1998,共6页中国化学（英文版）

基　　金：funding from the National Natural Science Foundation of China(Nos.22071111 and 22371125);Jiangsu Specially Appointed Professor Plan,and Postgraduate Research&Practice Innovation Program of Jiangsu Province of China(No.KYCX23_1683).

摘　　要：The stereochemical synthesis of highly substituted Danishefsky-type dienes remains unsolved in organic chemistry.We describe a simple and efficient approach for the stereoselective synthesis of Danishefsky-type trisubstituted dienes from readily available propargylic esters via Pd-catalyzed dienylation reaction through the key intermediate metallacyclobutene in a regio-,chemo-and stereoselective fashion.This method facilitates a broad range of challenging trisubstituted dienes with a high level of stereocontrol.

关 键 词：Propargylic ester Dienylation DIENE STEREOSELECTIVITY CYCLOADDITION Palladium β-H elimination Regioselectivity 

分 类 号：O62[理学—有机化学]