Chiral Lewis Base/Achiral Acid Co-Catalyzed Atroposelective Sulfenylation of Pyrrole Derivatives: Construction of C-N Axially Chiral Sulfides  

作　　者：Qin Yang Hui-Yun Luo Deng Zhu Xin-Yu Zhang Hua Ke Zhi-Min Chen 

机构地区：[1]School of Chemistry and Chemical Engineering,Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,Shanghai Jiao Tong University,Shanghai 200240,China [2]Engineering Technooy Rearch Centeror Enviromental Proction Materas,Pingxng Universty Pingang,Jiangx355,China [3]State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu 730000,China

出　　处：《Chinese Journal of Chemistry》2024年第17期2005-2009,共5页中国化学（英文版）

基　　金：Z.-M.Chen thanks National Natural Science Foundation of China(22071149,21871178);Natural Science Foundation of Shanghai(23ZR1428200);financial support.H.Ke thanks Natural Science Foundation of Jiangxi Province(20202ACBL213005)for financial support.

摘　　要：Chiral BINAM-derived selenide/achiral acid co-catalyzed atroposelective electrophilic sulfenylation of pyrrole derivatives has been realized for the first time.A variety of C-N axially chiral sulfur-containing pyrrole derivatives were readily obtained in moderate to good yields with moderate to excellent enantioselectivities.This catalytic system involves sequential desymmetrization and kinetic resolution.

关 键 词：Electrophilic substitution DESYMMETRIZATION Kinetic resolution ATROPISOMERISM Asymmetric catalysis HETEROCYCLES 

分 类 号：O62[理学—有机化学]