Burril-Bernard Crohn(1884-1983)and the disease which bears his name  

作　　者：Georgios Androutsos Konstantinos Laios Pavlos Lytsikas-Sarlis Evangelia Mourellou Constantinos Georgios Zografos Gregory Tsoucalas Marianna Karamanou 

机构地区：[1]School of Medicine,National and Kapodistrian University of Athens,Athens 11527,Greece [2]Department of History of Medicine and Medical Ethics,School of Medicine,National and Kapodistrian University of Athens,Athens 11527,Greece [3]Graduate School of Medicine,National and Kapodistrian University of Athens,Athens 11527,Greece [4]Department of the History of Medicine and Medical Deontology,School of Medicine,University of Crete,Heraklion 71003,Greece [5]Surgery Department,School of Medicine,National and Kapodistrian University of Athens,Athens 11527,Greece

出　　处：《History & Philosophy of Medicine》2024年第4期16-23,共8页医学史与医学哲学

摘　　要：Background:Crohn’s disease,described by Dr.Burrill Crohn and his colleagues in 1932,continues to be of great research and clinical interest.It was initially perceived as a distinct condition and it has evolved since into a complex disease,with debates still going regarding its classification and etiology.Even though more that 80 years of research have passed,numerous significant questions regarding the disease’s causes and best possible treatment strategies still remain.Methods:This article reviews both historical and contemporary perspectives on Crohn’s disease,including its initial description,the research developments that happened in the years to follow,as well as the way it is regarded nowadays.It refers to notable contributions from medical figures,such as Dr.Crohn and his colleagues,examines related advances made in medical research and mentions the challenges and the treatment strategies that are still being discussed.Results:This article highlights the evolution of Crohn’s disease from a distinct condition to a more heterogeneous one.Furthermore,it refers to advancements made in medical research,such as the identification of CARD15(NOD2)gene mutations and the role of dysbiosis,and it examines current therapeutic approaches.Conclusion:Even though significant progress has been made since the initial description of Chron’s disease,there is no definitive cure,even though it has been determined that genetic and environmental factors are of great importance.The ongoing research could possibly lead to future discoveries and therefore aid in the discovery of efficient management and treatment of Crohn’s disease.

关 键 词：regional ileitis granulomatous inflammation endoscopic evaluation historical figures 

分 类 号：R57[医药卫生—消化系统]