南京市溧水区多中心胃癌前病变状况人群调查  

A multicenter population investigation on precancerous lesions of gastric cancer in Lishui District,Nanjing

作　　者：牛春燕 王小平 赵向阳 黄健康 陈跃 石永强 宋用强 王辉 吴新国 卜永丹 李箕进 陶涛 吴金华 薛昌林 张福玉 杨金明 韩春荣 袁娟 武银铃 熊红兵 肖鹏 NIU Chunyan;WANG Xiaoping;ZHAO Xiangyang;HUANG Jiankang;CHEN Yue;SHI Yongqiang;SONG Yongqiang;WANG Hui;WU Xinguo;BU Yongdan;LI Jijin;TAO Tao;WU Jinhua;XUE Changlin;ZHANG Fuyu;YANG Jinming;HAN Chunrong;YUAN Juan;WU Yinling;XIONG Hongbing;XIAO Peng(Department of Gastroenterology,Nanjing Lishui District Peoples Hospital,Nanjing 211200,Jiangsu,China;不详)

机构地区：[1]南京市溧水区人民医院消化内科,江苏南京211200 [2]南京市溧水区人民医院神经内科,江苏南京211200 [3]南京市溧水区东屏街道卫生院,江苏南京211212 [4]南京市溧水区晶桥中心卫生院,江苏南京211224 [5]南京市溧水区洪蓝街道卫生院,江苏南京211219 [6]南京市溧水区石湫中心卫生院,江苏南京211222 [7]南京市溧水区白马中心卫生院,江苏南京211225 [8]南京市溧水区永阳街道社区卫生服务中心,江苏南京211299 [9]南京市溧水区人民医院内镜中心,江苏南京211200 [10]南京市溧水区人民医院病理科,江苏南京211200 [11]南京市溧水区人民医院医共体办公室,江苏南京211200 [12]南京市溧水区人民医院公共卫生科,江苏南京211200 [13]南京市溧水区人民医院院部,江苏南京211200

出　　处：《实用医学杂志》2024年第20期2929-2934,共6页The Journal of Practical Medicine

基　　金：江苏省“双创博士”计划项目(编号:JSSCBS20211551);南京大学中国医院改革发展研究院课题项目(编号:NDYG2023037)。

摘　　要：目的通过人群调查,了解南京市溧水区胃癌癌前病变及幽门螺杆菌(H.pylori)感染流行特征,为早期胃癌防治提供客观依据。方法2021年7月至2022年12月接受胃镜检查者21977例,回顾性分析人口学特征、胃癌前病变检出率、H.pylori感染率。结果(1)检出胃癌前病变590例(检出率2.68%);(2)男性癌前病变总检出率及各级别病理类型检出率均高于女性(P<0.001);(3)男性癌前病变最低检出年龄及各病理类型检出最低年龄均低于女性(P<0.001、P<0.009、P<0.005、P<0.002);(4)人群总H.pylori感染率23.10%,癌前病变者H.pylori感染率高于非癌前病变者(P<0.001),男性、女性癌前病变者H.pylori感染率均高于同性别非癌前病变者(P<0.001),男性癌前病变及非癌前病变者H.pylori感染率均高于女性(P<0.001);H.pylori感染率同样与年龄增长呈正相关(P<0.001),年龄变化趋势与癌前病变检出率趋势平行(P<0.001)。结论本区域内胃癌前病变检出率处于国内中等偏上水平,男性检出高于女性;女性癌前病变最低检出平均年龄较男性延迟10.57岁;调查人群总H.pylori感染率处于国内较低水平,随年龄增长而升高。Objective By population survey,to explore the epidemiological characteristics of gastric precancerous lesions in Lishui District of Nanjing and provide objective basis for the prevention and treatment of early gastric cancer.Methods From July 2021 to December 2022,21977 patients who received endoscopy and/or 13C-UBT in Lishui District People's Hospital and 6 medical community units in Nanjing City were retrospectively analyzed for demography characteristics,detection rate of gastric precancerous lesions,and H.Pylori infection rate.Results(1)590 cases of gastric precancerous lesions were detected(detection rate 2.68%);(2)The total detection rate of precancerous lesions and three pathological types in males were all higher than those in females(all P<0.001);(3)The minimum age for the total detection rate of precancerous lesions in males and the minimum age for each pathological type were lower than in females(P<0.001,0.009,0.005,0.002);(4)The population total H.pylori infection rate was 23.10%,the H.pylori infection rate in patients with precancerous lesions was higher than that in non-precancerous lesions(P<0.001),both H.pylori infection rate of male and female in precancerous lesions were all higher than those of non-precancerous lesions of the same sex(all P<0.001),in addition,the H.pylori infection rate of male whether in precancerous or non-precancerous lesions was higher than that of female(all P<0.001);(5)The precancerous lesions detection rate in male,female,and the overall age range of 20~29 to 70~79 years is positively correlated with age growth(P<0.001),and rapidly decreases after the age of 79,the of H.pylori infection rate was also positively correlated with age growth(P<0.001),and the trend of age change(P<0.001)was parallel to the precancerous lesions detection rate.Conclusions The detection rate of gastric precancerous lesions in this region is above the average level in China;the total H.pylori infection rate is at a relatively low level in China;the H.pylori infection rate is parallel to the age t

关 键 词：胃癌前病变 早期胃癌 幽门螺杆菌(H.pylori) 感染率 流行特征 

分 类 号：R735.2[医药卫生—肿瘤]