精神分裂症中氧化应激相关通路与诊断和预测价值的研究进展  

Advances in oxidative stress-related pathways with diagnostic and predictive value in schizophrenia

作　　者：俞天悦 郭茜[1] 胡昊[1] 苏宇静 陈剑华[1] YU Tianyue;GUO Qian;HU Hao;SU Yujing;CHEN Jianhua(Shanghai Jiao Tong University School of Medicine Affiliated Mental Health Center,Shanghai Mental Health Center,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海市精神卫生中心,上海200030

出　　处：《实用医学杂志》2024年第20期2935-2940,共6页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82071500);上海市“科技创新行动计划”优秀学科带头人项目(编号:21XD1423300);上海市浦江人才计划(编号:21PJD063)。

摘　　要：精神分裂症是一种疾病负担较重的重性精神疾病。氧化应激与促炎因子的交互作用相互叠加促进慢性神经炎症和免疫损伤,导致多巴胺能和谷氨酸能通路失调,出现精神病性症状,与精神分裂症的病理机制息息相关。该文从色氨酸犬尿氨酸代谢通路、WNT/β-Catenin通路与NF-κB通路、多巴胺代谢这3条研究较为集中,涉及炎症和氧化应激相互作用的通路中寻找生物标志物,并讨论相关的抗氧化剂在精神分裂症诊治中的应用,总结其当前研究进展。Schizophrenia is a severe mental illness with a significant disease burden.The interaction between oxidative stress and pro-inflammatory factors promotes chronic neuroinflammation and immune damage,leads to dysregulation of dopaminergic and glutamatergic pathways and occurrence of psychotic symptoms and is believed to be closely related to the pathogenesis of schizophrenia.In this paper,we aim to identify biomarkers within the tryptophan kynurenine metabolic pathway,the WNT/β-Catenin pathway and the NF-κB pathway,and dopamine metabolism.These pathways have been extensively studied and are known to be involved in the interaction between inflammation and oxidative stress.We will also explore the potential application of related antioxidants in the diagnosis and treatment of schizophrenia,summarizing their current research progress.

关 键 词：氧化应激 炎症因子 精神分裂症 生物标志物 

分 类 号：R749.3[医药卫生—神经病学与精神病学]