替罗非班配合介入取栓治疗对急性缺血性脑卒中患者神经功能、凝血功能指标的影响分析  

The effect analysis of tirofiban combined with interventional thrombectomy on neurological and coagulation function indicators of acute ischemic stroke patients

作　　者：周芳贵 ZHOU Fang-gui(Department of Neurology,Jianou Municipal Hospital,Jianou 353100,China)

机构地区：[1]福建省建瓯市立医院神经内科,353100

出　　处：《中国现代药物应用》2024年第19期1-5,共5页Chinese Journal of Modern Drug Application

摘　　要：目的分析替罗非班配合介入取栓治疗对急性缺血性脑卒中(AIS)患者神经功能、凝血功能指标的影响。方法选取AIS患者80例,随机分为对照组和观察组,各40例。对照组行介入取栓治疗,观察组在介入取栓基础上加以替罗非班治疗。对比两组临床疗效、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分、中枢神经特异性蛋白(S100β)、脑源性神经营养因子(BDNF)、神经生长因子(NGF)]、凝血功能指标[凝血酶原时间(PT)、纤维蛋白原(FIB)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)]、炎症因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平、生活质量及不良事件发生情况。结果观察组治疗总有效率92.50%较对照组的75.00%高(P<0.05)。治疗后,两组NIHSS评分、S100β较治疗前降低,BDNF、NGF较治疗前升高,且观察组NIHSS评分(6.59±0.97)分、S100β(0.31±0.02)μg/L较对照组的(9.41±1.25)分、(0.47±0.05)μg/L低,BDNF(46.56±4.21)ng/ml、NGF(12.41±2.57)pg/ml较对照组的(36.75±3.41)ng/ml、(8.83±2.26)pg/ml高(P<0.05)。治疗后,两组PT、APTT、TT较治疗前延长,FIB较治疗前降低,且观察组PT(12.83±2.35)s、APTT(30.48±3.71)s、TT(17.98±2.84)s较对照组的(11.27±1.95)、(26.84±3.05)、(15.39±2.18)s长,FIB(2.98±0.35)g/L较对照组的(3.53±0.61)g/L低(P<0.05)。治疗后,两组IL-6、CRP、TNF-α较治疗前降低,且观察组IL-6(67.54±8.97)pg/ml、CRP(4.69±1.05)mg/L、TNF-α(5.35±1.16)ng/ml较对照组的(86.71±11.35)pg/ml、(7.53±1.67)mg/L、(8.71±1.53)ng/ml低(P<0.05)。治疗后,两组心理功能、躯体功能、社会功能及物质生活状态评分较治疗前升高,且观察组心理功能、躯体功能、社会功能及物质生活状态评分较对照组高(P<0.05)。两组不良事件发生率对比无差异(P>0.05)。结论替罗非班配合介入取栓治疗可保护AIS患者神经功能,改善凝血功能,控制炎症反应,提高生活质量,且无严重不�Objective To analyze the effect of tirofiban combined with interventional thrombectomy on neurological and coagulation function indicators of acute ischemic stroke(AIS)patients.Methods A total of 80 AIS patients were randomly divided into a control group and an observation group,with 40 patients in each group.The control group received interventional thrombectomy,while the observation group received treatment with tirofiban.Comparison was made on the clinical efficacy,neurological function[National Institutes of Health Stroke Scale(NIHSS)score,central nervous specific protein-β(S100β),brain-derived neurotrophic factor(BDNF),nerve growth factor(NGF)],coagulation function indicators[prothrombin time(PT),fibrinogen(FIB),thrombin time(TT),activated partial thromboplastin time(APTT)],inflammatory cytokine[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]levels,quality of life,and occurrence of adverse events between two groups.Results The total effective rate of 92.50%in the observation group was higher than 75.00%in the control group(P<0.05).After treatment,NIHSS score and S100βin both groups were lower than those before treatment,and BDNF and NGF were higher than those before treatment;the observation group had NIHSS score of(6.59±0.97)points and S100βof(0.31±0.02)μg/L,which were lower than(9.41±1.25)points and(0.47±0.05)μg/L in the control group;the observation group had BDNF of(46.56±4.21)ng/ml and NGF of(12.41±2.57)pg/ml,which were higher than(36.75±3.41)ng/ml and(8.83±2.26)pg/ml in the control group(P<0.05).After treatment,PT,APTT and TT in both groups were longer than those before treatment,and FIB was lower than that before treatment;the observation group had PT of(12.83±2.35)s,APTT of(30.48±3.71)s and TT of(17.98±2.84)s,which were longer than(11.27±1.95),(26.84±3.05)and(15.39±2.18)s in the control group;FIB of(2.98±0.35)g/L in the observation group was lower than(3.53±0.61)g/L in the control group(P<0.05).After treatment,IL-6,CRP and TNF-αdecreased in both gr

关 键 词：急性缺血性脑卒中 替罗非班 介入取栓 神经功能 脑源性神经营养因子 凝血酶时间 

分 类 号：R743.3[医药卫生—神经病学与精神病学]