氟西汀治疗老年癫痫伴轻中度抑郁患者的效果及对抑郁的改善作用  

The Effect of Fluoxetine in the Treatment of Elderly Epilepsy Patients with Mild to Moderate Depression and Its Improvement on Depression Scores

作　　者：安娜 AN Na(Department of Psychiatry,Shandong Xintai Mental Hospital,Xintai 271200,Shandong,China)

机构地区：[1]山东省新泰市精神病医院精神科,山东新泰271200

出　　处：《系统医学》2024年第17期38-40,47,共4页Systems Medicine

摘　　要：目的分析氟西汀治疗老年癫痫伴轻中度抑郁患者的效果及对抑郁的改善作用。方法非随机选取2022年2月—2023年9月山东省新泰市精神病医院收治的88例老年癫痫轻中度抑郁患者为研究对象,按治疗方法不同分为观察组和对照组,各44例。两组患者均采取常规抗癫痫治疗,观察组加用氟西汀治疗。对比两组患者治疗效果、抑郁评分和不良反应发生情况。结果观察组治疗总有效率为97.73%(43/44),高于对照组的81.82%(36/44),差异有统计学意义(χ^(2)=4.456,P<0.05)。观察组治疗4、6、8周的汉密顿抑郁量表评分低于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论老年癫痫伴轻中度抑郁患者采取氟西汀治疗有确切优势,能够有效改善患者的疾病症状,且不增加不良反应。Objective To analyze the efficacy of fluoxetine in the treatment of elderly epilepsy patients with mild to moderate depression and its improvement effect on depression.Methods Eighty-eight elderly patients with mild to moderate depression caused by epilepsy admitted to Xintai Mental Hospital in Shandong Province from February 2022 to September 2023 were non-randomly selected as the research subjects.They were divided into an observation group and a control group according to different treatment methods,with forty-four cases in each group.Both groups of pa-tients received routine antiepileptic treatment,while the observation group received additional treatment with fluox-etine.Compare the treatment outcomes,depression scores,and incidence of adverse reactions between two groups of patients.Results The total effective rate of the observation group was 97.73%(43/44),which was higher than 81.82%(36/44)of the control group,and the difference was statistically significant(χ^(2)=4.456,P<0.05).The Hamilton Depres-sion Rating Scale scores of the observation group were lower than those of the control group at 4,6,and 8 weeks of treatment,and the differences were statistically significant(all P<0.05).There was no statistically significant differ-ence in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of fluoxetine in the treatment of elderly patients with epilepsy and mild to moderate depression has definite advantages,as it can effec-tively improve the patient's disease symptoms without increasing adverse reactions.

关 键 词：氟西汀 老年癫痫 轻中度抑郁 抑郁评分 

分 类 号：R749.4[医药卫生—神经病学与精神病学]