脑梗死早期阿替普酶静脉溶栓的临床疗效分析  

Observation of Clinical Efficacy of Intravenous Thrombolysis with Ateplase in Early Stage of Cerebral Infarction

作　　者：潘成永 唐欢 徐丰 冒春华 邱耀 PAN Chengyong;TANG Huan;XU Feng;MAO Chunhua;QIU Yao(Department of Neurology,Suqian Third Hospital,Suqian 223800,Jiangsu,China;Suqian Hospital of Integrated Traditional Chinese and Western Medicine,Suqian 223800,Jiangsu,China)

机构地区：[1]宿迁市第三医院神经内科,江苏宿迁223800 [2]宿迁市中西医结合医院,江苏宿迁223800

出　　处：《系统医学》2024年第17期87-89,94,共4页Systems Medicine

摘　　要：目的探讨早期脑梗死患者接受阿替普酶静脉溶栓治疗的临床疗效。方法非随机选取2021年1月—2022年12月宿迁市第三医院收治的52例早期脑梗死患者为研究对象,根据治疗方式划分为两组,即常规治疗组(n=26,接受常规对症治疗)和静脉溶栓组(n=26,接受阿替普酶静脉溶栓治疗)。对比两组患者的神经功能评分、Barthel评分及凝血酶原时间、凝血酶时间、部分凝血酶时间及临床治疗有效率。结果与常规治疗组相比,静脉溶栓组Barthel评分提高、神经功能评分降低,凝血指标升高,差异有统计学意义(P均<0.05)。静脉溶栓组的治疗有效率为100.00%(26/26),高于常规治疗组的76.92%(20/26),差异有统计学意义(χ^(2)=4.710,P<0.05)。结论对早期脑梗死患者给予阿替普酶静脉溶栓治疗法进行干预能够有效改善其神经缺损情况,提高生活自理能力。Objective To investigate the clinical effect of alteplase intravenous thrombolytic therapy in patients with early cerebral infarction.Methods A total of fifty-two patients with early cerebral infarction admitted to the Third Hospital of Suqian City from January 2021 to December 2022 were non-randomly selected as the study subjects and divided into two groups according to treatment methods:conventional treatment group(n=26,receiving conventional symptomatic treatment)and intravenous thrombolysis group(n=26,receiving alteplase intravenous thrombolysis).The neurological function score,Barthel score,prothrombin time,thrombin time,partial thrombin time and clinical efficacy of the two groups were compared.Results Compared with the conventional treatment group,the Barthel score in the in-travenous thrombolysis group was increased,the nerve function score was decreased,and the coagulation index was in-creased,the differences were statistically significant(all P<0.05).The effective rate of intravenous thrombolysis group was 100.00%(26/26),which was higher than 76.92%(20/26)of conventional treatment group,the difference was sta-tistically significant(χ^(2)=4.710,P<0.05).Conclusion Alteplase intravenous thrombolytic therapy can effectively im-prove nerve defect and self-care ability of patients with early cerebral infarction.

关 键 词：早期脑梗死 阿替普酶 静脉溶栓 神经功能 凝血指标 

分 类 号：R74[医药卫生—神经病学与精神病学]