宫颈鳞癌组织中ELF5、Ki-67、p53表达及与临床病理关系  

Correlation between the expressions of ELF5,Ki-67,and p53 in cervical squamous cell carcinoma tissues of patients and their clinical pathology

作　　者：施卓钰 闫洪超 SHI Zhuoyu;YAN Hongchao(Graduate school,Xuxhou Medical Umiversity,Xuxhou,Jiangsu Province,221004;The Affiliated Hospital of Xuthou Medical University)

机构地区：[1]徐州医科大学研究生院,221004 [2]徐州医科大学附属医院

出　　处：《中国计划生育学杂志》2024年第10期2423-2428,共6页Chinese Journal of Family Planning

基　　金：徐州市卫生健康委青年医学科技创新项目(XWKYHT20220146)。

摘　　要：目的:分析宫颈鳞癌病变组织中Ki-67、p53及ELF5表达情况及与宫颈鳞癌临床病理特征的关联性。方法:选择2019年9月-2022年12月在医院接受手术且手术后病理诊断为宫颈鳞状细胞癌患者50例的肿瘤组织样本,良性疾病手术后病理确诊为慢性子宫颈炎患者30例组织样本为对照组。免疫组织化学(IHC)技术检测样本组织中Ki-67、p53、ELF5的表达水平,统计阳性表达与临床病理参数。结果:宫颈鳞状组Ki-67、p53、ELF5的阳性表达率(92.0%、72.0%、60.0%)、高于对照组(3.3%、10.0%、13.3%)(均P<0.05)。宫颈鳞癌组Ki-67的表达与淋巴血管间隙侵犯(LVSI)有关,p53表达与病理分级、浸润深度有关,ELF5表达与宫颈鳞癌的国际妇产科联盟(FIGO)分期、浸润深度、肿瘤径线有关,Ki-67表达与宫颈鳞癌的病理分级、LVSI正相关,p53表达与病理分级和浸润深度正相关,ELF5表达与宫颈鳞状细胞癌的FIGO分期、病理分级、浸润深度和肿瘤径线正相关,Ki-67与p53、ELF5的表达呈正相关(均P<0.05),而p53与ELF5之间无明显相关性。结论:ELF5蛋白、p53蛋白与Ki-67蛋白在宫颈鳞癌发生发展中表达存在相关性,有助于宫颈癌诊断,为早期治疗提供有益帮助。Objective:To explore the expressions of Ki-67,p53,and ELF5 in the cervical squamous carcinoma lesions tissues of the patients,and to analyze the correlation between the expressions of ELF5,Ki-67,and p53 in cervical squamous cell carcinoma tissues of the patients and their clinical pathology.Methods:The tumor tissue samples of 50 patients with cervical squamous cell carcinoma(CSCC)diagnosed by pathology who had undergone surgery were selected in study group,and the tumor tissue samples of 30 patients with chronic cervicit diagnosed by pathology who had undergone surgery were selected in control group from September 2019 to December 2022.The expression levels of Ki-67,p53,and ELF5 in the tissue samples of the patients in the two groups were examined by immunohistochemistry(IHC).The positive expressions of Ki-67,p53,and ELF5 and the clinical pathological parameters values of the patients in the two groups were statistically counted.Results:The positive expression rates of Ki-67,p53 and ELF5(92.0%,72.0%and 60.0%)of the patients in the study group were significantly higher than those(3.3%,10.0%and 13.3%)of the patients in the control group(all P<0.05).In the study group,the expression of Ki-67 of the patients was related to the lymphovascular space invasion(LVSI)of their CSCC,the expression of p53 of the patients was related to the pathological grade and depth of invasion of their CSCC,and the expression of ELF5 of the patients was related to the CSCC stage by federation of international gynecology and obstetrics(FIGO),the depth of invasion and the tumor diameter of their CSCC.The expression of Ki-67 of the patients was positively related to their pathological grade and LVSI of CSCC.The expression of ELF5 of the patients was positively correlated with their FIGO stage,pathological grade,invasion depth and tumor diameter of CSCC.The expression of Ki-67 of the patients was positively correlated with their expression of p53 and ELF5(all P<0.05),but there was no significant correlation between the expression of p53 of the

关 键 词：宫颈鳞癌 ELF5 KI-67 p53 病理特征 相关性 

分 类 号：R737.33[医药卫生—肿瘤]