替吉奥联合奥沙利铂对中晚期胃癌患者的治疗效果  

Therapeutic Effect of Tegafur Combined with Oxaliplatin on Patients with Middle-Advanced Gastric Carcinoma

作　　者：曹静 郭玉霞 王秀娟 CAO Jing;GUO Yuxia;WANG Xiujuan(Department of Tumor Radiotherapy,Zhumadian First People's Hospital,Zhumadian 463000,China;Department of Tumor Internal Medicine,Zhumadian First People's Hospital,Zhumadian 463000,China;Department of Intervention,Zhumadian First People's Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市第一人民医院肿瘤放疗科,河南驻马店463000 [2]驻马店市第一人民医院肿瘤内科,河南驻马店463000 [3]驻马店市第一人民医院介入科,河南驻马店463000

出　　处：《临床医学工程》2024年第10期1235-1236,共2页Clinical Medicine & Engineering

摘　　要：目的探讨替吉奥联合奥沙利铂治疗中晚期胃癌(GC)患者的临床效果。方法选取2019年8月至2020年8月我院收治的中晚期GC患者65例,根据治疗方法的不同分为A组(32例)和B组(33例)。A组接受替吉奥联合奥沙利铂治疗,B组接受卡培他滨联合奥沙利铂治疗。比较两组的临床疗效,胃泌素(GAS)及survivin抗体水平,以及毒副反应。结果A组的治疗总有效率为68.75%,高于B组的42.42%(P<0.05)。治疗4个周期后,A组的血清GAS及survivin抗体水平均低于B组(P<0.05)。A组的恶心呕吐、脱发、肝肾损伤、白细胞减少发生率与B组比较,差异无统计学意义(P>0.05)。结论替吉奥联合奥沙利铂治疗中晚期GC患者的效果确切,可明显降低患者的血清GAS及survivin抗体水平,且未明显增加毒副反应发生风险。Objective To explore the clinical effect of tegafur combined with oxaliplatin in the treatment of patients with middleadvanced gastric carcinoma(GC).Methods A total of 65 patients with middle-advanced GC admitted to our hospital from August 2019 to August 2020 were selected and divided into group A(32 cases)and group B(33 cases)according to different treatment methods.Group A was treated with tegafur combined with oxaliplatin,and group B was treated with capecitabine combined with oxaliplatin.The clinical efficacy,gastrin(GAS)and survivin antibody levels,and toxic side effects were compared between the two groups.Results The total effective rate of treatment in group A was 68.75%,higher than 42.42%in group B(P<0.05).After 4 cycles of treatment,the levels of serum GAS and survivin antibody in group A were lower than those in group B(P<0.05).No significant difference was found in the incidences of nausea and vomiting,alopecia,liver and kidney injury,and leukopenia between group A and group B(P>0.05).Conclusions Tegafur combined with oxaliplatin in the treatment of patients with middle-advanced GC has exact effect,which can obviously reduce the serum GAS and survivin antibody levels of patients,and does not significantly increase the occurrence risk of toxic side effects.

关 键 词：中晚期胃癌 替吉奥 奥沙利铂 胃泌素 SURVIVIN抗体 

分 类 号：R735.2[医药卫生—肿瘤]