血清尿酸、半胱氨酸蛋白酶抑制剂C及碱性磷酸酶水平与脑卒中后抑郁的相关性  

Relationship of Serum Uric Acid、Cystatin C and Alkaline Phosphatase Levels with Post-stroke Depression

作　　者：杨琴[1] 王新新 YANG Qin;WANG Xinxin(Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院神经内科,河南郑州450052

出　　处：《河南医学研究》2024年第19期3478-3481,共4页Henan Medical Research

摘　　要：目的分析血清尿酸、半胱氨酸蛋白酶抑制剂C(Cys C)及碱性磷酸酶水平与脑卒中后抑郁(PSD)的相关性。方法收集郑州大学第一附属医院诊治的202例脑卒中患者的临床资料,经神经内科治疗后病情稳定,根据汉密尔顿抑郁量表(HAMD)评分,分为抑郁组(105例)与对照组(共97例)。收集两组患者的一般临床基线资料和实验室指标,应用logistic回归分析急性脑卒中患者PSD发生的危险因素,根据受试者工作特征(ROC)曲线分析血清尿酸、Cys C水平预测PSD发生的临床价值。结果两组性别、高血压、糖尿病、吸烟、饮酒、冠心病、房颤史、发病类型、发病至入院时间及碱性磷酸酶水平比较,差异无统计学意义(P>0.05)。两组患者高龄、美国国立卫生研究院卒中量表(NIHSS)评分、血清尿酸和Cys C水平差异有统计学意义(P<0.05)。logistic回归分析结果提示,血清尿酸水平和Cys C水平是急性脑卒中患者发生PSD的影响因素。血清尿酸浓度预测PSD的最临界值为317.251μmol·L^(-1)。血清Cys C浓度预测PSD的最佳临界值为2.155 mg·L^(-1)。结论血清碱性磷酸酶水平与PSD的发生无关;血清尿酸和Cys C水平是影响急性脑卒中患者发生PSD的独立影响因素,二者对急性脑卒中患者发生PSD具有较高的诊断价值,可以作为预测PSD发生的血清学指标。Objective To analyze the relationship of serum uric,acid,cystatin C(Cys C)and alkaline phosphatase levels after post-stroke depression(PSD).Methods The clinical data of 202 patients with acute stroke diagnosed and treated in the First Affiliated Hospital of Zhengzhou University were analyzed retrospectively,and their condition was stable after neurological treatment.The patients were divided into depression group(105 cases)and control group(97 cases)according to Hamilton depression rating scale(HAMD)score.The general clinical data and laboratory data of the two groups were collected,and the risk factors for PSD in acute stroke patients were analyzed by logistic regression.The clinical value of serum uric acid and Cys C levels in predicting PSD was analyzed according to the receiver operating characteristic(ROC)curve.Results There were no statistically significant differences between the two groups in terms of gender,hypertension,diabetes mellitus,diabetes mellitus,smoking,alcohol consumption,coronary heart disease,history of atrial fibrillation,incidence type,time from onset to hospital admission and serum alkaline phosphatase levels(P>0.05).There were significant differences between the PSD group and the control group in terms of advanced age,National Institute of Health stroke scale(NIHSS)score,serum uric acid and Cys C levels(P<0.05).Logistic regression analysis suggested that serum uric acid level and Cys C level were the influencing factors for PSD in patients with acute stroke.The most critical value of serum uric acid concentration for predicting PSD was 317.251μmol·L^(-1).The optimal cut-off value for serum Cys C concentration to predict PSD was 2.155 mg·L^(-1).Conclusion There was no correlation between serum alkaline phosphatase levels and the development of PSD.Serum uric acid and Cys C levels are influencing factors for the development of PSD in patients with acute stroke,and their serum levels have high diagnostic value for the development of PSD in patients with acute stroke,and can be used as a

关 键 词：急性脑卒中 抑郁症 尿酸 半胱氨酸蛋白酶抑制剂C 碱性磷酸酶 

分 类 号：R743[医药卫生—神经病学与精神病学]