血清CYFRA21-1、VEGF、AFP、CA19-9和SCC水平对食管癌的诊断价值  

Diagnostic Value of Serum CYFRA21-1,VEGF,AFP,CA19-9 and SCC Levels in Esophageal Cancer

作　　者：黄永杰 赵铁锁[1] 李晓童 李灵招 HUANG Yongjie;ZHAO Tiesuo;LI Xiaotong;LI Lingzhao(Department of Immunology,School of Basic Medicine,Xinxiang Medical University,Xinxiang 453000,China;Department of Laboratory Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]新乡医学院基础医学院免疫学系,河南新乡453000 [2]郑州大学附属郑州中心医院检验科,河南郑州450000

出　　处：《河南医学研究》2024年第19期3490-3494,共5页Henan Medical Research

基　　金：河南省高等学校重点科研项目计划(24B320021)。

摘　　要：目的探究血清细胞角蛋白19片段(CYFRA21-1)、血管内皮生长因子(VEGF)、甲胎蛋白(AFP)、糖类抗原19-9(CA19-9)和鳞状细胞癌抗原(SCC)水平对食管癌的诊断价值。方法选取2022年2月至2024年2月郑州大学附属郑州中心医院收治的86例食管癌患者的临床资料开展回顾性分析(研究组),另按2∶1比例选取郑州大学附属郑州中心医院同期体检的43名健康人群的临床资料进行对照研究(对照组),比较两组血清CYFRA21-1、VEGF、AFP、CA19-9和SCC水平差异,并通过受试者工作特征(ROC)曲线分析其诊断食管癌的价值。分析血清CYFRA21-1、VEGF、AFP、CA19-9和SCC水平与食管癌病理特征的关系。结果研究组血清CYFRA21-1、VEGF、AFP、CA19-9和SCC水平均高于对照组(P<0.05)。二元logistic回归分析结果显示,CYFRA21-1、VEGF、AFP、CA19-9、SCC均是影响食管癌发病危险因素(P<0.05)。ROC曲线分析显示,血清CYFRA21-1、VEGF、AFP、CA19-9和SCC水平诊断食管癌的AUC分别为0.747、0.779、0.745、0.749、0.765,诊断具有一定价值。联合数据诊断食管癌的AUC为0.855,敏感度为90.7%、特异性为98.5%。肿瘤≥3 cm患者血清CYFRA21-1、VEGF、AFP、CA19-9和SCC水平均高于肿瘤<3 cm患者;临床分期Ⅲ~Ⅳ期患者血清CYFRA21-1、VEGF、AFP、CA19-9和SCC水平均高于Ⅰ~Ⅱ期患者;存在淋巴结转移患者血清CYFRA21-1、VEGF、AFP、CA19-9和SCC水平均高于未发生淋巴结转移患者(P<0.05)。结论食管癌患者血清CYFRA21-1、VEGF、AFP、CA19-9、SCC水平升高,且与食管癌临床特征密切相关,是食管癌发生的危险因素,可作为诊断食管癌的相关指标,且联合诊断价值更好。Objective To explore the diagnostic value of serum cytokeratin 19 fragment antigen 21-1(CYFRA21-1),vascular endothelial growth factor(VEGF),alpha-fetoprotein(AFP),carbohydrate antigen 19-9(CA19-9)and squamous cell carcinoma antigen(SCC)levels in esophageal cancer.Methods The clinical data of 86 patients with esophageal cancer admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from February 2022 to February 2024 were analyzed retrospectively(study group),and the clinical data of 43 healthy people in Zhengzhou Central Hospital Affiliated to Zhengzhou University at the same time were selected for control study(control group).The differences of serum CYFRA21-1,VEGF,AFP,CA19-9 and SCC levels between the two groups were compared,and their diagnostic value for esophageal cancer were analyzed by ROC curve.The relationship between the serum levels of CYFRA21-1,VEGF,AFP,CA19-9 and SCC and the pathological features of esophageal cancer was analyzed.Results The serum levels of CYFRA21-1,VEGF,AFP,CA19-9 and SCC in the study group were higher than those in the control group(P<0.05).The results of binary Logistic regression analysis showed that CYFRA21-1,VEGF,AFP,CA19-9 and SCC were all risk factors of esophageal cancer(P<0.05).ROC curve analysis showed that serum levels of CYFRA21-1,VEGF,AFP,CA19-9 and SCC were 0.747,0.779,0.745,0.749 and 0.765,respectively,which had certain diagnostic value.The AUC of combined data in diagnosing esophageal cancer was 0.855,the sensitivity was 90.7%,and the specificity was 98.5%.Serum CYFRA21-1,VEGF,AFP,CA19-9 and SCC levels of tumor size≥3 cm patients were higher than those of tumor size<3 cm patients.Serum CYFRA21-1,VEGF,AFP,CA19-9 and SCC levels of clinical stageⅢ~Ⅳpatients were higher than those of stageⅠ-Ⅱpatients.Serum CYFRA21-1,VEGF,AFP,CA19-9 and SCC levels of patients with lymph node metastasis were higher than those of patients without lymph node metastasis(P<0.05).Conclusion The levels of serum CYFRA21-1,VEGF,AFP,CA19-9 and SCC in patients with esoph

关 键 词：食管癌 细胞角蛋白19片段 血管内皮生长因子 甲胎蛋白 糖类抗原19-9 鳞状细胞癌抗原 诊断价值 

分 类 号：R735.1[医药卫生—肿瘤]