甲状腺癌术后应用益气养阴化瘀方对患者内分泌功能、免疫功能的影响  

Effect of Yiqi Yangyin Huayu Formula on Endocrine Function and Immune Function of Patients with Thyroid Cancer After Operation

作　　者：邢栋[1] 吴峰[1] 王松[1] 王宙[1] 安秋冬 孙浩杰 XING Dong;WU Feng;WANG Song;WANG Zhou;AN Qiudong;SUN Haojie(Department of General Surgery,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院普外科,河南郑州450000

出　　处：《河南医学研究》2024年第19期3593-3597,共5页Henan Medical Research

摘　　要：目的研究甲状腺癌术后应用益气养阴化瘀方对患者内分泌功能、免疫功能的影响。方法将2021年2月至2022年7月河南中医药大学第一附属医院收治的60例甲状腺癌术后患者随机分为左甲状腺素组(30例)和益气养阴化瘀组(30例)。左甲状腺素组接受左甲状腺素片进行治疗,在左甲状腺素组的基础上,益气养阴化瘀组接受益气养阴化瘀方进行治疗,两组均治疗3个月。统计两组治疗3个月后的疗效,比较两组治疗前和治疗3个月后中医证候积分、内分泌功能、免疫功能、血清炎症因子水平、心理状态及生活质量。结果治疗3个月后,益气养阴化瘀组总有效率高于左甲状腺素组(P<0.05)。治疗3个月后,益气养阴化瘀组中医证候积分、外周血CD8^(+)水平、白介素-17A(IL-17A)较治疗前降低,且低于左甲状腺素组(P<0.05);两组血清游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、多巴胺(DA)水平较治疗前升高,益气养阴化瘀组高于左甲状腺素组(P<0.05);两组血清促甲状腺激素(TSH)、白介素-6(IL-6)、C反应蛋白(CRP)水平、抑郁自评量表(SDS)、焦虑自评量表(SAS)评分较治疗前降低,益气养阴化瘀组低于左甲状腺素组(P<0.05)。益气养阴化瘀组外周血CD3^(+)、CD4^(+)水平、血清白介素-10(IL-10)水平及CD4^(+)/CD8^(+)较治疗前升高,且高于左甲状腺素组(P<0.05);左甲状腺素组生活质量评分较治疗前升高,且高于益气养阴化瘀组(P<0.05)。结论应用益气养阴化瘀方治疗甲状腺癌术后患者,可有效改善中医证候、内分泌功能,提高机体免疫功能,降低其炎症反应,改善其心理状态,有助于维持其生活质量,具有较好的治疗效果。Objective To study the effects of Yiqi Yangyin Huayu Formula on endocrine function and immune function of patients with thyroid cancer after surgery.Methods A total of 60 patients with thyroid cancer treated in the First Affiliated Hospital of Henan University of Chinese Medicine from February 2021 to July 2022 after surgery were randomly divided into levothyroxine group(30 cases)and Yiqi Yangyin Huayu group(30 cases).Levothyroxine group was treated with levothyroxine tablets,and on the basis of levothyroxine group,Yiqi Yangyin Huayu group was treated with Yiqi Yangyin Huayu Formula.Both groups were treated for 3 months.The efficacy of the two groups after 3 months of treatment was analyzed,and the traditional Chinese medicine syndrome score,endocrine function,immune function,serum inflammatory factor level,psychological state and quality of life of the two groups were compared before and after 3 months of treatment.Results After 3 months of treatment,the total effective rate of Yiqi Yangyin Huayu group was higher than that of levothyroxine group(P<0.05).After 3 months of treatment,traditional Chinese medicine syndrome score,peripheral blood CD8+level and interleukin-17A(IL-17A)in Yiqi Yangyin Huayu group were lower than before treatment,and lower than levothyroxine group(P<0.05).Serum levels of free triiodothyronine(FT_(3)),free thyroxine(FT_(4))and dopamine(DA)in two groups were higher than those before treatment,and those in Yiqi Yangyin Huayu group were higher than levothyroxine group(P<0.05).Serum levels of thyroid stimulating hormone(TSH),interleukin-6(IL-6),C-reactive protein(CRP),self-rating depression scale(SDS)and self-rating anxiety scale(SAS)in both groups were lower than those before treatment,and those in Yiqi Yangyin Huayu group were lower than levethyroxine group(P<0.05).The levels of peripheral blood CD3+,CD4+,serum interleukin-10(IL-10)and CD4+/CD8+in Yiqi Yangyin Huayu group were higher than those before treatment,and higher than those in levothyroxine group(P<0.05).The quality of life score in

关 键 词：甲状腺癌 益气养阴化瘀方 左甲状腺素片 内分泌功能 免疫功能 

分 类 号：R736.1[医药卫生—肿瘤]