大麻二酚治疗耐药性癫痫研究进展  

Advances in the treatment of drug-resistant epilepsy with cannabidiol

作　　者：王继芬 叶兰 冯占辉 WANG Ji-fen;YE Lan;FENG Zhan-hui(Department of Neurology,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;Department of Neurology,Xingyi People's Hospital,Xingyi 562400,China;School of Basic Medicine,Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学附属医院神经内科,贵阳550004 [2]兴义市人民医院神经内科,兴义562400 [3]贵州医科大学基础医学院,贵阳550004

出　　处：《中国新药杂志》2024年第19期2044-2049,共6页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(81960224,82360266);贵州省科技厅资助项目(黔科合基础-ZK[2023]一般395,黔科合基础-ZK[2023]一般324)。

摘　　要：全球约7 000万人罹患癫痫,在我国癫痫患者约1 000万例。癫痫的一线治疗方案为使用抗癫痫发作药物,尽管目前不断有抗癫痫药物获批上市,然而癫痫耐药患者人数仍占癫痫患者总人数的30%。大麻二酚(cannabidiol, CBD)是一种天然存在的具有抗癫痫特性的大麻素,临床研究结果表明CBD对Dravet综合征、Lennox Gastaut综合征、结节性硬化性癫痫等耐药性癫痫取得了良好的治疗效果,其作用机制广泛,安全性良好,已获得美国FDA批准上市。本文总结了耐药性癫痫发病机制和CBD治疗不同类型耐药性癫痫的疗效、机制和安全性,为临床进一步了解CBD提供参考。There are approximately 70 million people suffering from epilepsy around the world with about 10 million epilepsy patients in China.The main treatment of epilepsy is anti-seizure medicine.Despite the continuous development of these drugs,around 30%of epilepsy patients still experience drug resistance.Cannabidiol(CBD)is a natural cannabinoid that has been found anti-epileptic properties.Clinical studies have shown that CBD is effective in treating drug-resistant epilepsy,including conditions such as Dravet syndrome,Lennox Gastaut syndrome,and tuberous sclerosis epilepsy.CBD has a wide range of action mechanism and is considered safe,thus it has been approved by the US Food and Drug Administration.This article provides a summary of the pathogenesis of drug-resistant epilepsy,the efficacy,the mechanism,and safety of CBD in treating different types of drug-resistant epilepsy,aiming to provide epilepsy specialists with a reference to enhance their understanding of CBD.

关 键 词：癫痫 耐药性癫痫 大麻二酚 DRAVET综合征 LENNOX-GASTAUT综合征 结节性硬化 

分 类 号：R971.6[医药卫生—药品]